RT Journal Article
T1 Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer
A1 Mao, Ziling
A1 Aglago, Elom K.
A1 Zhao, Zhiwei
A1 Schalkwijk, Casper
A1 Jiao, Li
A1 Freisling, Heinz
A1 Weiderpass, Elisabete
A1 Hughes, David J.
A1 Eriksen, Anne Kirstine
A1 Tjonneland, Anne
A1 Severi, Gianluca
A1 Rothwell, Joseph
A1 Boutron-Ruault, Marie-Christine
A1 Katzke, Verena
A1 Kaaks, Rudolf
A1 Schulze, Matthias B.
A1 Birukov, Anna
A1 Krogh, Vittorio
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Bueno-de-Mesquita, H. Bas
A1 Vermeulen, Roel C. H.
A1 Gram, Inger T.
A1 Skeie, Guri
A1 Sandanger, Torkjel M.
A1 Quiros, J. Ramon
A1 Crous-Bou, Marta
A1 Sanchez, Maria-Jose
A1 Amiano, Pilar
A1 Chirlaque, Maria-Dolores
A1 Barricarte Gurrea, Aurelio
A1 Manjer, Jonas
A1 Johansson, Ingegerd
A1 Perez-Cornago, Aurora
A1 Jenab, Mazda
A1 Fedirko, Veronika
K1 advanced glycation end-products
K1 dietary advanced glycation end-products
K1 all-cause mortality
K1 colorectal cancer mortality
K1 Coronary-heart-disease
K1 Carboxymethyl-lysine
K1 Oxidative stress
K1 Cardiovascular-disease
K1 Breast-cancer
K1 Endproducts
K1 Inflammation
K1 Glycotoxins
K1 Risk
K1 Restriction
AB Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, P-interaction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, P-interaction = 0.003; all-cause, P-interaction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
PB Mdpi
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/24690
UL https://hdl.handle.net/10668/24690
LA en
DS RISalud
RD Apr 7, 2025