RT Conference Proceedings
T1 Activated protein C consumption and coagulation parameters in severe sepsis and septic shock.
A1 Torre-Prados, M de la
A1 García-de la Torre, A
A1 Trujillano-Fernández, C
A1 Pérez-Vacas, J
A1 Puerto-Morlán, A
A1 Cámara-Sola, E
K1 Choque séptico
K1 Pruebas de coagulación sanguínea
K1 Pronóstico
K1 Proteina C
K1 Tasa de supervivencia
K1 Unidades de cuidados intensivos
AB Introduction Activated protein C (APC) deC ciency is prevalent in severe sepsis and septic shock patients. The aim of the study was to relate the anticoagulation activity evaluated by APC with other coagulationparameters adjusted to 28-day mortality.Methods A cohort study of 150 critically ill adults. Age, sex, sources of infection and coagulation markers within 24< hours from severe sepsis or septic shock onset, deC ned according to Surviving Sepsis Campaign (SSC) criteria, were studied. We analyzed APC activity using a hemostasis laboratory analyzer (BCS® XP; Siemens). A descriptive and comparative statistical analysis was performed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA).Results We analyzed 150 consecutive episodes of severe sepsis (16%) or septic shock (84%) admitted to the UCI. The median age of the study sample was 64 (interquartile range (IQR): 22.3<years; male: 60%). The main sources of infection were: respiratory tract 38%, intra-abdomen 45%, and 70.7% had medical pathology. The 28-day mortality was22.7%. Nonsurvivors had a signiC cantly higher consumption of APC than survivors, 56% (IQR: 38.5) versus 68.6 (IQR: 41.4); P = 0.023. The proC le of lower levels of APC was a surgery patient with septic shock,neurological focus or catheter-related infection and Gram-negative pathogens from blood cultures. Spearman’s showed relationship with antithrombin III, r<= 0.674 (P <0.001) and International Normalized Ratio (INR), r<= –0.611 (P >0.001). See Figure 1. Conclusion Low levels of PC are associated with poor outcome andseverity in severe sepsis, and it is well correlated with antithrombin III and INR.
PB BioMed Central
SN 1364-8535
YR 2014
FD 2014-03
LK http://hdl.handle.net/10668/1815
UL http://hdl.handle.net/10668/1815
LA en
NO Torre-Prados M de la, García-de la Torre A, Trujillano-Fernández C, Pérez-Vacas J, Puerto-Morlán A, Cámara-Sola E. Activated protein C consumption and coagulation parameters in severe sepsis and septic shock. Critical Care. 2014;18(Suppl. 1):S80-S81
NO Meeting abstract
DS RISalud
RD Apr 5, 2025