RT Journal Article
T1 Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper.
A1 Fieten, Karin B
A1 Drijver-Messelink, Marieke T
A1 Cogo, Annalisa
A1 Charpin, Denis
A1 Sokolowska, Milena
A1 Agache, Ioana
A1 Taborda-Barata, Luis Manuel
A1 Eguiluz-Gracia, Ibon
A1 Braunstahl, Gerrit J
A1 Seys, Sven F
A1 van-den-Berge, Maarten
A1 Bloch, Konrad E
A1 Ulrich, Silvia
A1 Cardoso-Vigueros, Carlos
A1 Kappen, Jasper H
A1 Brinke, Anneke Ten
A1 Koch, Markus
A1 Traidl-Hoffmann, Claudia
A1 da Mata, Pedro
A1 Prins, David J
A1 Pasmans, Suzanne G M A
A1 Bendien, Sarah
A1 Rukhadze, Maia
A1 Shamji, Mohamed H
A1 Couto, Mariana
A1 Oude Elberink, Hanneke
A1 Peroni, Diego G
A1 Piacentini, Giorgio
A1 Weersink, Els J M
A1 Bonini, Matteo
A1 Rijssenbeek-Nouwens, Lucia H M
A1 Akdis, Cezmi A
K1 Altitude
K1 Asthma
K1 Climate
K1 Environment
K1 Pulmonary rehabilitation
AB Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro-immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.
PB John Wiley & Sons
YR 2022
FD 2022-01-30
LK http://hdl.handle.net/10668/19896
UL http://hdl.handle.net/10668/19896
LA en
NO Fieten KB, Drijver-Messelink MT, Cogo A, Charpin D, Sokolowska M, Agache I, et al. Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper. Allergy. 2022 Jul;77(7):1991-2024
DS RISalud
RD Apr 18, 2025