RT Journal Article
T1 LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia.
A1 Cuadros, Marta
A1 Garcia, Daniel J
A1 Andrades, Alvaro
A1 Arenas, Alberto M
A1 Coira, Isabel F
A1 Baliñas-Gavira, Carlos
A1 Peinado, Paola
A1 Rodriguez, Maria I
A1 Alvarez-Perez, Juan Carlos
A1 Ruiz-Cabello, Francisco
A1 Camos, Mireia
A1 Jimenez-Velasco, Antonio
A1 Medina, Pedro P
K1 AL133346.1
K1 CCN2
K1 CTGF
K1 Biomarker
K1 LncRNA expression
K1 Pediatric B-ALL
AB Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL datasets (Therapeutically Applicable Research to Generate Effective Treatments, Cancer Cell Line Encyclopedia). Survival curve analysis demonstrated that patients with "high" expression levels of CCN2 had higher overall survival than those with "low" levels (p = 0.042), and this gene might be an independent prognostic biomarker in pediatric B-ALL. These findings provide one of the first detailed descriptions of lncRNA expression profiles in pediatric B-ALL and indicate that these potential biomarkers could help in the classification of leukemia subtypes and that CCN2 expression could predict the survival outcome of pediatric B-cell acute lymphoblastic leukemia patients.
PB MDPI
SN 2072-6694
YR 2020
FD 2020-12-17
LK https://hdl.handle.net/10668/28439
UL https://hdl.handle.net/10668/28439
LA en
NO Cuadros M, García DJ, Andrades A, Arenas AM, Coira IF, Baliñas-Gavira C, et al.  LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia. Cancers (Basel). 2020 Dec 17;12(12):3803
DS RISalud
RD Apr 18, 2025