RT Journal Article
T1 Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
A1 Cárdenas, Casimiro
A1 Torres-Vargas, José Antonio
A1 Cárdenas-Valdivia, Abel
A1 Jurado, Nuria
A1 Quesada, Ana R.
A1 García-Caballero, Melissa
A1 Martínez-Poveda, Beatriz
A1 Medina, Miguel Ángel
K1 Ultra-high-performance liquid
K1 Chromatography-high-resolution mass spectrometry (UHPLC–HRMS)
K1 Annona muricata
K1 Graviola
K1 Soursop
K1 Angiogenesis
K1 Cromatografía líquida de alta presión
K1 Espectrometría de masas
K1 Annonaceae
K1 Annona
K1 Neovascularización fisiológica
AB The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
PB Elsevier Masson SAS
SN 0753-3322
YR 2021
FD 2021-10-06
LK http://hdl.handle.net/10668/4594
UL http://hdl.handle.net/10668/4594
LA en
NO Cárdenas C, Torres-Vargas JA, Cárdenas-Valdivia A, Jurado N, Quesada AR, García-Caballero M, et al. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomed Pharmacother. 2021 Dec;144:112263
DS RISalud
RD Apr 18, 2025