RT Journal Article T1 Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A1 Zamora-Ros, Raul A1 Alghamdi, Muath A A1 Cayssials, Valerie A1 Franceschi, Silvia A1 Almquist, Martin A1 Hennings, Joakim A1 Sandström, Maria A1 Tsilidis, Konstantinos K A1 Weiderpass, Elisabete A1 Boutron-Ruault, Marie-Christine A1 Hammer Bech, Bodil A1 Overvad, Kim A1 Tjønneland, Anne A1 Petersen, Kristina E N A1 Mancini, Francesca Romana A1 Mahamat-Saleh, Yahya A1 Bonnet, Fabrice A1 Kühn, Tilman A1 Fortner, Renée T A1 Boeing, Heiner A1 Trichopoulou, Antonia A1 Bamia, Christina A1 Martimianaki, Georgia A1 Masala, Giovanna A1 Grioni, Sara A1 Panico, Salvatore A1 Tumino, Rosario A1 Fasanelli, Francesca A1 Skeie, Guri A1 Braaten, Tonje A1 Lasheras, Cristina A1 Salamanca-Fernández, Elena A1 Amiano, Pilar A1 Chirlaque, Maria-Dolores A1 Barricarte, Aurelio A1 Manjer, Jonas A1 Wallström, Peter A1 Bueno-de-Mesquita, H Bas A1 Peeters, Petra H A1 Khaw, Kay-Thee A1 Wareham, Nicholas J A1 Schmidt, Julie A A1 Aune, Dagfinn A1 Byrnes, Graham A1 Scalbert, Augustin A1 Agudo, Antonio A1 Rinaldi, Sabina K1 Coffee K1 Cohort K1 EPIC K1 Intake K1 Tea K1 Thyroid cancer AB Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97-1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95-1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95-1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81-0.99), but this association was based on a sub-analysis with a small number of cancer cases. In this large prospective study, coffee and tea consumptions were not associated with TC risk. YR 2018 FD 2018-12-10 LK http://hdl.handle.net/10668/13306 UL http://hdl.handle.net/10668/13306 LA en DS RISalud RD Apr 8, 2025