RT Journal Article
T1 Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.
A1 Agúndez, José A G
A1 Barrio, Jaime del
A1 Padró, Teresa
A1 Stephens, Camilla
A1 Farré, Magí
A1 Andrade, Raúl J
A1 Badimón, Lina
A1 García-Martín, Elena
A1 Vilahur, Gemma
A1 Lucena, M Isabel
K1 Biomarkers
K1 Pharmacogenomics
K1 drug safety
K1 drug-induced liver injury
K1 Enfermedad Hepática Inducida por Drogas
K1 Marcadores Biológicos
AB In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have long been pursuing. Thirty years ago, when molecular pharmacogenomics evolved, we anticipated that these genetic biomarkers would soon obviate the routine use of drug therapies in a way that patients should adapt to the therapy rather than the opposite. This expected revolution in routine clinical practice never took place as quickly nor with the intensity as initially expected. The concerted action of operating multicenter networks holds great promise for future studies to identify biomarkers related to drug toxicity and to provide better insight into the underlying pathogenesis. Today some pharmacogenomic advances are already widely accepted, but pharmacogenomics still needs further development to elaborate more precise algorithms and many barriers to implementing individualized medicine exist. We briefly discuss our view about these barriers and we provide suggestions and areas of focus to advance in the field.
PB Frontiers Research Foundation
YR 2012
FD 2012-01-19
LK http://hdl.handle.net/10668/898
UL http://hdl.handle.net/10668/898
LA en
NO Agúndez JA, Del Barrio J, Padró T, Stephens C, Farré M, Andrade RJ, et al. Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology. Frontiers in Pharmacol. 2012; 3:2
NO Journal Article. This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
DS RISalud
RD Apr 17, 2025