RT Journal Article
T1 Serotypes and genotypes of S. pneumoniae isolates from adult invasive disease in Spain: A 5-year prospective surveillance after pediatric PCV13 licensure. The ODIN study.
A1 Fenoll, Asunción
A1 Ardanuy, Carmen
A1 Liñares, Josefina
A1 Cercenado, Emilia
A1 Marco, Francesc
A1 Fleites, Ana
A1 Rodríguez-Mayo, María
A1 López-Hontangas, Jose-Luis
A1 Palop, Begoña
A1 Aller, Ana-Isabel
A1 Buendía, Buenaventura
A1 Méndez, Cristina
A1 Cifuentes, Isabel
A1 ODIN Study Group, 
K1 Clonal complex
K1 Invasive pneumococcal disease
K1 PCV13
K1 Serotype
K1 Streptococcus pneumoniae
AB Serotypes/genotypes causing invasive pneumococcal disease (IPD) in adults are determined by vaccination strategies. The aim of this study was to assess the epidemiology of IPD in adults (≥18 years) after PCV13 introduction for children: serotypes, clonal complexes, antibiotic non-susceptibility and clinical presentations. We performed a prospective, clinical surveillance of hospitalized culture-confirmed IPDs in adults in nine Spanish hospitals (August 2010-June 2015). A total of 1087 culture-confirmed IPD episodes were included, of which 772 (71.0%) had bacteremic pneumonia (401 complicated/371 uncomplicated pneumonia), 122 (11.2%) meningitis, 102 (9.4%) non-focal bacteremia, 34 (3.1%) peritonitis and 57 (5.3%) others. The most common serotypes were: 3 (12.7%), 19A (8.5%), 8 (7.7%), 7F (6.3%), 1 (4.2%), 6C (4.2%), 11A (4.2%), 22F (4.2%) and 14 (4.0%). Vaccine types (PCV13 + 6C) caused 49.8% of IPD episodes, with a significant decrease over the 5-year period, and significant decreases in serotypes 6C and 7F. The most common genotypes were: CC180 (8.4%), CC191 (6.0%), and CC53 (5.0%). Vaccine types caused 53.9% (414/768) pneumonia episodes and 58.9% (235/399) complicated pneumonia, 53.4% IPD in adults
YR 2018
FD 2018-11-16
LK http://hdl.handle.net/10668/13204
UL http://hdl.handle.net/10668/13204
LA en
DS RISalud
RD Apr 8, 2025