%0 Journal Article
%A Fenoll, Asunción
%A Ardanuy, Carmen
%A Liñares, Josefina
%A Cercenado, Emilia
%A Marco, Francesc
%A Fleites, Ana
%A Rodríguez-Mayo, María
%A López-Hontangas, Jose-Luis
%A Palop, Begoña
%A Aller, Ana-Isabel
%A Buendía, Buenaventura
%A Méndez, Cristina
%A Cifuentes, Isabel
%A ODIN Study Group
%T Serotypes and genotypes of S. pneumoniae isolates from adult invasive disease in Spain: A 5-year prospective surveillance after pediatric PCV13 licensure. The ODIN study.
%D 2018
%U http://hdl.handle.net/10668/13204
%X Serotypes/genotypes causing invasive pneumococcal disease (IPD) in adults are determined by vaccination strategies. The aim of this study was to assess the epidemiology of IPD in adults (≥18 years) after PCV13 introduction for children: serotypes, clonal complexes, antibiotic non-susceptibility and clinical presentations. We performed a prospective, clinical surveillance of hospitalized culture-confirmed IPDs in adults in nine Spanish hospitals (August 2010-June 2015). A total of 1087 culture-confirmed IPD episodes were included, of which 772 (71.0%) had bacteremic pneumonia (401 complicated/371 uncomplicated pneumonia), 122 (11.2%) meningitis, 102 (9.4%) non-focal bacteremia, 34 (3.1%) peritonitis and 57 (5.3%) others. The most common serotypes were: 3 (12.7%), 19A (8.5%), 8 (7.7%), 7F (6.3%), 1 (4.2%), 6C (4.2%), 11A (4.2%), 22F (4.2%) and 14 (4.0%). Vaccine types (PCV13 + 6C) caused 49.8% of IPD episodes, with a significant decrease over the 5-year period, and significant decreases in serotypes 6C and 7F. The most common genotypes were: CC180 (8.4%), CC191 (6.0%), and CC53 (5.0%). Vaccine types caused 53.9% (414/768) pneumonia episodes and 58.9% (235/399) complicated pneumonia, 53.4% IPD in adults
%K Clonal complex
%K Invasive pneumococcal disease
%K PCV13
%K Serotype
%K Streptococcus pneumoniae
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