RT Journal Article
T1 The Role of Glycosyltransferases in Colorectal Cancer.
A1 Fernandez-Ponce, Cecilia
A1 Geribaldi-Doldan, Noelia
A1 Sanchez-Gomar, Ismael
A1 Quiroz, Roberto Navarro
A1 Ibarra, Linda Atencio
A1 Escorcia, Lorena Gomez
A1 Fernandez-Cisnal, Ricardo
A1 Martinez, Gustavo Aroca
A1 Garcia-Cozar, Francisco
A1 Quiroz, Elkin Navarro
K1 Colorectal cancer (CRC)
K1 Glycosylation
K1 Glycosyltransferase
K1 Post-translational modification
AB Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-translational modifications (PTMs) have been extensively studied in malignancies due to its relevance in tumor pathogenesis and therapy. This review is focused on the dysregulation of glycosyltransferase expression in CRC and its impact in cell function and in several biological pathways associated with CRC pathogenesis, prognosis and therapeutic approaches. Glycan structures act as interface molecules between cells and their environment and in several cases facilitate molecule function. CRC tissue shows alterations in glycan structures decorating molecules, such as annexin-1, mucins, heat shock protein 90 (Hsp90), β1 integrin, carcinoembryonic antigen (CEA), epidermal growth factor receptor (EGFR), insulin-like growth factor-binding protein 3 (IGFBP3), transforming growth factor beta (TGF-β) receptors, Fas (CD95), PD-L1, decorin, sorbin and SH3 domain-containing protein 1 (SORBS1), CD147 and glycosphingolipids. All of these are described as key molecules in oncogenesis and metastasis. Therefore, glycosylation in CRC can affect cell migration, cell-cell adhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemness regulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization and gut microbiota composition; all such functions are associated with the prognosis and evolution of the disease. According to these findings, multiple strategies have been evaluated to alter oligosaccharide processing and to modify glycoconjugate structures in order to control CRC progression and prevent metastasis. Additionally, immunotherapy approaches have contemplated the use of neo-antigens, generated by altered glycosylation, as targets for tumor-specific T cells or engineered CAR (Chimeric antigen receptors) T cells.
PB MDPI
YR 2021
FD 2021-05-27
LK http://hdl.handle.net/10668/17922
UL http://hdl.handle.net/10668/17922
LA en
NO Fernández-Ponce C, Geribaldi-Doldán N, Sánchez-Gomar I, Quiroz RN, Ibarra LA, Escorcia LG, et al. The Role of Glycosyltransferases in Colorectal Cancer. Int J Mol Sci. 2021 May 30;22(11):5822
DS RISalud
RD Apr 7, 2025