RT Journal Article
T1 The variability of respiratory symptoms and associated factors in COPD.
A1 Miravitlles, Marc
A1 Izquierdo, José Luis
A1 Esquinas, Cristina
A1 Pérez, Maite
A1 Calle, Myriam
A1 López-Campos, José Luis
A1 Rodríguez González-Moro, José Miguel
A1 Casanova, Ciro
A1 Esteban, Cristóbal
A1 de Lucas, Pilar
K1 COPD
K1 Quality of life
K1 Sleep
K1 Symptoms
K1 Variability
AB Few studies have investigated the variability of COPD-related symptoms or factors related to symptom variability. This observational, prospective, multicentre study was conducted to describe the number and intensity of morning and night-time respiratory symptoms and their variability over one week using the Night-time and Early Morning Symptoms of COPD Instruments (NiSCI and EMSCI) to evaluate stable COPD patients. Logistic regression analyses were performed to investigate factors associated with symptom variability. A total of 2669 patients were evaluated (mean age, 67.7 years; 80.9% men; mean FEV1 50.6%). Of these, 48% reported night-time symptoms and 71% reported morning symptoms. Of the 2293 patients who completed the NiSCI and EMSCI, 90% showed variability in either symptom number (89.6%) or symptom intensity (15.8%). More severe dyspnoea, more exacerbations during the previous year and the exacerbator or mixed COPD-asthma phenotypes were associated with variability in symptom number or intensity. Anxiety was significantly associated with variability in symptom number and intensity. Most COPD patients showed symptom variability over a weeklong period, especially in terms of symptom number. Several COPD-related factors, mainly factors related to more severe disease and more frequent exacerbations, were associated with increased symptom variability.
YR 2017
FD 2017-06-26
LK http://hdl.handle.net/10668/11429
UL http://hdl.handle.net/10668/11429
LA en
DS RISalud
RD Apr 12, 2025