%0 Journal Article
%A Troya, Jesús
%A Ryan, Pablo
%A Ribera, Esteban
%A Podzamczer, Daniel
%A Hontañón, Victor
%A Terrón, Jose Alberto
%A Boix, Vicente
%A Moreno, Santiago
%A Barrufet, Pilar
%A Castaño, Manuel
%A Carrero, Ana
%A Galindo, María José
%A Suárez-Lozano, Ignacio
%A Knobel, Hernando
%A Raffo, Miguel
%A Solís, Javier
%A Yllescas, María
%A Esteban, Herminia
%A González-García, Juan
%A Berenguer, Juan
%A Imaz, Arkaitz
%T Abacavir/Lamivudine plus Rilpivirine Is an Effective and Safe Strategy for HIV-1 Suppressed Patients: 48 Week Results of the SIMRIKI Retrospective Study.
%D 2016
%U http://hdl.handle.net/10668/2520
%X OBJECTIVESBased on data from clinical practice, we evaluated the effectiveness and safety of switching to abacavir/lamivudine plus rilpivirine (ABC/3TC+RPV) treatment in virologically suppressed HIV-1-infected patients.METHODSWe performed a multicenter, non-controlled, retrospective study of HIV-1-infected patients who switched treatment to ABC/3TC+RPV. Patients had an HIV-RNA <50 copies/mL for at least 24 weeks prior to changing treatments. The primary objective was HIV-1 RNA <50 copies/mL at week 48. Effectiveness was analyzed by intention-to-treat (ITT), missing = failure and on-treatment (OT) analyses. The secondary objectives analyzed were adverse effects changes in renal, hepatic or lipid profiles, changes in CD4+ cell count and treatment discontinuations.RESULTSOf the 205 patients included, 75.6% were men and the median age was 49. At baseline, before switching to ABC/3TC+RPV, median time since HIV diagnosis was 13.1 years, median time with undetectable HIV-1 RNA was 6.2 years and median time of previous antiretroviral regimen was 3.1 years (48.3% patients were taking efavirenz and ABC/3TC was the most frequent backbone coformulation in 69.7% of patients). The main reasons for switching were drug toxicity/poor tolerability (60.5%) and simplification (20%). At week 48, the primary objective was achieved by 187 out of 205 (91.2%) patients by ITT analysis, and 187 out of 192 (97.4%) patients by OT analysis. The CD4+ lymphocyte count and CD4+ percentage increased significantly from baseline to week 48 by a median of 48 cells/μL (-50 to 189) and 1.2% (-1.3% to 4.1%), respectively, P<0.001. Thirty-eight adverse events (AE) were detected in 32 patients. Of these, 25 had no clear association with treatment. Three patients interrupted therapy due to AE. We observed a decrease in all lipid parameters, P<0.001, and a slight improvement in the glomerular filtration rate, P<0.01. Therapy was considered to have failed in 18 patients owing to virological failure (5 [2.4%]), toxicity/poor tolerability (4 [2%]), clinical decision (3 [1.5%]), loss to follow-up (3 [1.5%]), death (1 [0.5%]), and no clinical data (2 [1%]).CONCLUSIONSThe results of this study confirms that ABC/3TC+RPV is an effective, safe, and cost-effective option for the treatment of patients with virologically stable HIV-1 infection.
%K Benzoxazinas
%K Recuento de Linfocito CD4
%K Didesoxinucleósidos
%K Combinación de medicamentos
%K Efectos colaterales y reacciones adversas relacionados con medicamentos
%K Estudios de seguimiento
%K Tasa de filtración glomerular
%K Infecciones por Vih
%K VIH-1
%K Humanos
%K Análisis de intención de tratar
%K Lamivudine
%K Lípidos
%K Masculino
%K ARN
%K Estudios retrospectivos
%K Rilpivirine
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