RT Journal Article
T1 Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma.
A1 Perez, Cristina
A1 Botta, Cirino
A1 Zabaleta, Aintzane
A1 Puig, Noemi
A1 Cedena, Maria-Teresa
A1 Goicoechea, Ibai
A1 Alameda, Daniel
A1 San José-Eneriz, Edurne
A1 Merino, Juana
A1 Rodríguez-Otero, Paula
A1 Maia, Catarina
A1 Alignani, Diego
A1 Maiso, Patricia
A1 Manrique, Irene
A1 Lara-Astiaso, David
A1 Vilas-Zornoza, Amaia
A1 Sarvide, Sarai
A1 Riillo, Caterina
A1 Rossi, Marco
A1 Rosiñol, Laura
A1 Oriol, Albert
A1 Blanchard, María-Jesús
A1 Rios, Rafael
A1 Sureda, Anna
A1 Martin, Jesus
A1 Martinez, Rafael
A1 Bargay, Joan
A1 de la Rubia, Javier
A1 Hernandez, Miguel-Teodoro
A1 Martinez-Lopez, Joaquin
A1 Orfao, Alberto
A1 Agirre, Xabier
A1 Prosper, Felipe
A1 Mateos, Maria-Victoria
A1 Lahuerta, Juan-José
A1 Blade, Joan
A1 San-Miguel, Jesús F
A1 Paiva, Bruno
AB Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and immunosuppression in multiple myeloma (MM). However, their phenotype is not well established for accurate monitoring or clinical translation. We aimed to provide the phenotypic profile of G-MDSCs based on their prognostic significance in MM, immunosuppressive potential, and molecular program. The preestablished phenotype of G-MDSCs was evaluated in bone marrow samples from controls and MM patients using multidimensional flow cytometry; surprisingly, we found that CD11b+CD14-CD15+CD33+HLADR- cells overlapped with common eosinophils and neutrophils, which were not expanded in MM patients. Therefore, we relied on automated clustering to unbiasedly identify all granulocytic subsets in the tumor microenvironment: basophils, eosinophils, and immature, intermediate, and mature neutrophils. In a series of 267 newly diagnosed MM patients (GEM2012MENOS65 trial), only the frequency of mature neutrophils at diagnosis was significantly associated with patient outcome, and a high mature neutrophil/T-cell ratio resulted in inferior progression-free survival (P
YR 2020
FD 2020
LK http://hdl.handle.net/10668/15418
UL http://hdl.handle.net/10668/15418
LA en
DS RISalud
RD Apr 10, 2025