RT Journal Article
T1 Venous and arterial TNF-R1 predicts outcome and complications in acute subarachnoid hemorrhage.
A1 Fragata, Isabel
A1 Bustamante, Alejandro
A1 Penalba, Anna
A1 Ferreira, Patrícia
A1 Nunes, Ana Paiva
A1 Canhão, Patrícia
A1 Montaner, Joan
K1 Delayed cerebral ischemia
K1 Hydrocephalus
K1 Prognosis
K1 Subarachnoid hemorrhage
K1 TNF-R1
AB There is increasing evidence for the role of inflammation in clinical outcome after subarachnoid hemorrhage (SAH). Specifically, the TNF-alfa(α) pathway seems to be relevant after SAH. Although the TNF-α main receptor, TNF-R1 is associated with aneurysm growth and rupture, its relation to prognosis is unknown. We sought to compare TNF-R1 levels in peripheral venous blood and arterial blood closer to the ruptured aneurysm to study the association of TNF-R1 blood levels with poor prognosis (modified Rankin Scale  > 2 at discharge, 3 and 6 months) and complications (hydrocephalus or delayed cerebral ischemia/DCI) following SAH. We included consecutive SAH patients admitted in the first 72 h of symptoms. Blood samples were simultaneously collected from a peripheral vein and from the main parent artery of the aneurysm. Levels of TNF-R1 were measured using enzyme-linked immunosorbent assays. We analyzed 58 patients. Arterial and venous levels of TNF-R1 were correlated (R = 0.706, p  Levels of venous TNF-R1 are associated with poor outcome in SAH. A specific association was found between levels of arterial TNF-R1 and hydrocephalus. These results are consistent with the role of TNF-α pathway in SAH and need to be validated in larger cohorts.
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13451
UL http://hdl.handle.net/10668/13451
LA en
DS RISalud
RD Apr 11, 2025