RT Journal Article T1 Synchronous occurrence of IgG4-related sialadenitis and ductal carcinoma of the parotid gland: a case report. A1 Rollon-Mayordomo, Angel A1 Avellaneda-Camarena, Ana A1 Gutierrez-Domingo, Alvaro A1 Martinez-Carapeto, Elena A1 Infante-Cossio, Pedro K1 IgG4-related sialadenitis (IgG4-RS) K1 Immunoglobulin G4-related disease (IgG4-RD) K1 case report K1 head and neck K1 parotid gland K1 salivary duct carcinoma AB Immunoglobulin G4-related disease (IgG4-RD) is a rare chronic systemic inflammatory pathology that poses a diagnostic challenge since it can simulate malignancy when it affects a salivary gland as a mass-like lesion. Here, the authors report an unusual clinical case of a 42-year-old man who presented with a painless, slow-growing swelling located in the right parotid gland with a 12-month evolution. Based on imaging tests and open biopsy, a diagnosis of chronic parotitis was presumed and oral methylprednisolone was prescribed. Due to poor response to medication, a total parotidectomy preserving the facial nerve was performed. The final pathology described a unilateral IgG4-related sialadenitis (IgG4-RS) in the parotid gland in combination with a poorly differentiated multifocal ductal carcinoma. The postoperative course was uneventful except for a temporary facial paresis (grade III according to the House-Brackmann classification system) that resolved completely within 5 months. There were no systemic manifestations on the whole-body 18F-FDG PET/CT. Adjuvant radiotherapy was administered without complications. Twenty-four months follow-up after surgery showed no recurrence or evidence of systemic involvement. This clinical report highlights the importance of considering the synchronous occurrence of a carcinoma underlying an isolated parotid gland mass in the context of IgG4-RS, especially if there is no response to prior steroid medication. SN 2227-684X YR 2021 FD 2021 LK http://hdl.handle.net/10668/18203 UL http://hdl.handle.net/10668/18203 LA en DS RISalud RD Apr 6, 2025