RT Journal Article
T1 Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study
A1 Herrmann, Florian
A1 Nieto-Ruiz, Ana
A1 Sepulveda-Valbuena, Natalia
A1 Miranda, M. Teresa
A1 Dieguez, Estefania
A1 Jimenez, Jesus
A1 De-Castellar, Roser
A1 Garcia-Ricobaraza, Maria
A1 Garcia-Santos, Jose Antonio
A1 Bermudez, Mercedes G.
A1 Campoy, Cristina
K1 Early nutrition
K1 Infection
K1 Milk fat globule membrane
K1 Respiratory-tract infections
K1 Double-blind
K1 Prebiotic oligosaccharides
K1 Probiotics
K1 Care
K1 Risk
K1 Efficacy
K1 Diarrhea
K1 Safety
K1 Prevention
AB Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age.
PB Elsevier BV
SN 1756-4646
YR 2021
FD 2021-05-02
LK http://hdl.handle.net/10668/18821
UL http://hdl.handle.net/10668/18821
LA en
NO Florian Herrmann, Ana Nieto-Ruiz, Natalia Sepúlveda-Valbuena, M. Teresa Miranda, Estefanía Diéguez, Jesús Jiménez, et al. Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study, Journal of Functional Foods, Volume 83, 2021, 104529,
DS RISalud
RD Apr 16, 2025