%0 Journal Article
%A Herrmann, Florian
%A Nieto-Ruiz, Ana
%A Sepulveda-Valbuena, Natalia
%A Miranda, M. Teresa
%A Dieguez, Estefania
%A Jimenez, Jesus
%A De-Castellar, Roser
%A Garcia-Ricobaraza, Maria
%A Garcia-Santos, Jose Antonio
%A Bermudez, Mercedes G.
%A Campoy, Cristina
%T Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study
%D 2021
%@ 1756-4646
%U http://hdl.handle.net/10668/18821
%X Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age.
%K Early nutrition
%K Infection
%K Milk fat globule membrane
%K Respiratory-tract infections
%K Double-blind
%K Prebiotic oligosaccharides
%K Probiotics
%K Care
%K Risk
%K Efficacy
%K Diarrhea
%K Safety
%K Prevention
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