RT Journal Article
T1 p53 and FBXW7: Sometimes Two Guardians Are Worse than One.
A1 Galindo-Moreno, María
A1 Giráldez, Servando
A1 Limón-Mortés, M Cristina
A1 Belmonte-Fernández, Alejandro
A1 Sáez, Carmen
A1 Japón, Miguel Á
A1 Tortolero, Maria
A1 Romero, Francisco
K1 FBXW7
K1 cancer
K1 p53
K1 proliferation
K1 tumor suppressor
K1 ubiquitylation
AB Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in tumor cell development. We also speculate about the function of FBXW7 as a key player in the cell fate after DNA damage and how this could be exploited in the treatment of cancer disease.
SN 2072-6694
YR 2020
FD 2020-04-16
LK https://hdl.handle.net/10668/27490
UL https://hdl.handle.net/10668/27490
LA en
DS RISalud
RD Apr 7, 2025