RT Generic
T1 Brainiac Caspases: Beyond the Wall of Apoptosis.
A1 Espinosa-Oliva, Ana Maria
A1 Garcia-Revilla, Juan
A1 Alonso-Bellido, Isabel Maria
A1 Burguillos, Miguel Angel
K1 astrocytes
K1 caspase
K1 inflammasome
K1 necroptosis
K1 neurodegeneration
K1 neuron
K1 oligodendrocytes
K1 pyroptosis
AB For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions. In this mini review, we focus on the most recent "non-apoptotic" roles of caspases in the CNS, particularly in neurons, astrocytes and oligodendrocytes. Non-apoptotic caspase functions in microglia have already been reviewed extensively elsewhere. Here we discuss the involvement of caspases in the activation of the inflammasome, autophagy, and non-apoptotic forms of cell death such as necroptosis and pyroptosis. Also, we review the involvement of caspases in synapses and the processing of aggregates key to neurodegenerative diseases such as Parkinson's, Alzheimer's and Huntington's diseases. Likewise, we mention the recently described involvement of caspases in mitochondrial biogenesis, which is a function independent of the enzymatic activity. We conclude discussing the relevance that "new" functions of caspases have in the CNS and the future of this field of research.
PB Frontiers Research Foundation
SN 1662-5102
YR 2019
FD 2019-11-05
LK http://hdl.handle.net/10668/14716
UL http://hdl.handle.net/10668/14716
LA en
NO Espinosa-Oliva AM, García-Revilla J, Alonso-Bellido IM, Burguillos MA. Brainiac Caspases: Beyond the Wall of Apoptosis. Front Cell Neurosci. 2019 Nov 5;13:500.
DS RISalud
RD Apr 18, 2025