%0 Journal Article
%A Luján-Sanchis, M
%A Pérez-Cuadrado-Robles, E
%A García-Lledó, J
%A Juanmartiñena Fernández, JF
%A Elli, L
%A Jiménez-García, VA
%A Egea-Valenzuela, J
%A Valle-Muñoz, J
%A Carretero-Ribón, C
%A Fernández-Urién-Sainz, I
%A López-Higueras, A
%A Alonso-Lázaro, N
%A Sanjuan-Acosta, M
%A Sánchez-Ceballos, F
%A Rosa, B
%A González-Vázquez, S
%A Branchi, F
%A Ruano-Díaz, I
%A Prieto-De-Frías, C
%A Pons-Beltrán, V
%A Borque-Barrera, P
%A González-Suárez, B
%A Xavier, S
%A Argüelles-Arias, F
%A Herrerías-Gutiérrez, JM
%A Pérez-Cuadrado-Martínez, E
%A Sempere-García-Argüelles, J
%T Role of capsule endoscopy in suspected celiac disease: A European multi-centre study
%D 2017
%@ 1007-9327
%U http://hdl.handle.net/10668/2649
%X AIM To analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE). METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group- ?, n = 19), seropositive CD without atrophy (Group- ?, n = 39), contraindication to gastroscopy (Group-?, n = 6), seronegative CD without atrophy, but with a compatible context (Group-?, n = 99). DY, TI and the safety of CE were analysed. RESULTS The overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn's). DY for groups ? to ? was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD. CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD. © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
%K Anti-transglutaminase antibodies
%K Capsule endoscopy
%K Celiac disease
%K Gluten-free diet
%K Non-celiac gluten sensitivity
%K Atrofia
%K Endoscopía capsular
%K Enfermedad celíaca
%K Enfermedad de Crohn
%~