TY - JOUR AU - El Bekay, Rajaa AU - Alba, Gonzalo AU - Reyes, M Edith AU - Chacón, Pedro AU - Vega, Antonio AU - Martín-Nieto, José AU - Jiménez, Juan AU - Ramos, Eladio AU - Oliván, Josefina AU - Pintado, Elizabeth AU - Sobrino, Francisco PY - 2007 DO - 10.1677/JME-07-0074 SN - 0952-5041 UR - http://hdl.handle.net/10668/355 T2 - Journal of Molecular Endocrinology AB - Angiotensin II (Ang II) highly stimulates superoxide anion production by neutrophils. The G-protein Rac2 modulates the activity of NADPH oxidase in response to various stimuli. Here, we describe that Ang II induced both Rac2 translocation from the... LA - en PB - European Society of Endocrinology KW - protein kinases KW - inflammation KW - Angiotensina KW - proteínas quinasas KW - inflamación KW - enfermedad cardiovascular KW - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Angiotensins::Angiotensin II KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Calcineurin KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Calcium Metabolism Disorders KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Biological Transport::Cell Membrane Permeability KW - Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic::Cyclosporins::Cyclosporine KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Enzyme Activation KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors::Angiotensin-Converting Enzyme Inhibitors KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein Kinases KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Granulocytes::Neutrophils KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Phosphatidylinositol 3-Kinases KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::GTP Phosphohydrolases::GTP-Binding Proteins::Monomeric GTP-Binding Proteins::rho GTP-Binding Proteins::rac GTP-Binding Proteins KW - Medical Subject Headings::Diseases::Cardiovascular Diseases TI - Rac2 GTPase activation by angiotensin II is modulated by Ca2C/calcineurin and mitogen-activated protein kinases in human neutrophils TY - research article ER -