RT Journal Article
T1 Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium.
A1 van Velzen, Laura S
A1 Dauvermann, Maria R
A1 Colic, Lejla
A1 Villa, Luca M
A1 Savage, Hannah S
A1 Toenders, Yara J
A1 Zhu, Alyssa H
A1 Bright, Joanna K
A1 Campos, Adrián I
A1 Salminen, Lauren E
A1 Ambrogi, Sonia
A1 Ayesa-Arriola, Rosa
A1 Banaj, Nerisa
A1 Başgöze, Zeynep
A1 Bauer, Jochen
A1 Blair, Karina
A1 Blair, Robert James
A1 Brosch, Katharina
A1 Cheng, Yuqi
A1 Colle, Romain
A1 Connolly, Colm G
A1 Corruble, Emmanuelle
A1 Couvy-Duchesne, Baptiste
A1 Crespo-Facorro, Benedicto
A1 Cullen, Kathryn R
A1 Dannlowski, Udo
A1 Davey, Christopher G
A1 Dohm, Katharina
A1 Fullerton, Janice M
A1 Gonul, Ali Saffet
A1 Gotlib, Ian H
A1 Grotegerd, Dominik
A1 Hahn, Tim
A1 Harrison, Ben J
A1 He, Mengxin
A1 Hickie, Ian B
A1 Ho, Tiffany C
A1 Iorfino, Frank
A1 Jansen, Andreas
A1 Jollant, Fabrice
A1 Kircher, Tilo
A1 Klimes-Dougan, Bonnie
A1 Klug, Melissa
A1 Leehr, Elisabeth J
A1 Lippard, Elizabeth T C
A1 McLaughlin, Katie A
A1 Meinert, Susanne
A1 Miller, Adam Bryant
A1 Mitchell, Philip B
A1 Mwangi, Benson
A1 Nenadić, Igor
A1 Ojha, Amar
A1 Overs, Bronwyn J
A1 Pfarr, Julia-Katharina
A1 Piras, Fabrizio
A1 Ringwald, Kai G
A1 Roberts, Gloria
A1 Romer, Georg
A1 Sanches, Marsal
A1 Sheridan, Margaret A
A1 Soares, Jair C
A1 Spalletta, Gianfranco
A1 Stein, Frederike
A1 Teresi, Giana I
A1 Tordesillas-Gutiérrez, Diana
A1 Uyar-Demir, Aslihan
A1 van der Wee, Nic J A
A1 van der Werff, Steven J
A1 Vermeiren, Robert R J M
A1 Winter, Alexandra
A1 Wu, Mon-Ju
A1 Yang, Tony T
A1 Thompson, Paul M
A1 Rentería, Miguel E
A1 Jahanshad, Neda
A1 Blumberg, Hilary P
A1 van Harmelen, Anne-Laura
A1 ENIGMA Suicidal Thoughts and Behaviours Consortium, 
A1 Schmaal, Lianne
AB Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen's d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.
YR 2022
FD 2022-09-07
LK http://hdl.handle.net/10668/22603
UL http://hdl.handle.net/10668/22603
LA en
DS RISalud
RD Apr 12, 2025