RT Journal Article
T1 Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study
A1 Salamanca-Fernández, Elena
A1 Rodríguez-Barranco, Miguel
A1 Amiano, Pilar
A1 Delfrade, Josu
A1 Chirlaque, Maria Dolores
A1 Colorado, Sandra
A1 Guevara, Marcela
A1 Jimenez, Ana
A1 Arrebola, Juan Pedro
A1 Vela, Fernando
A1 Olea, Nicolás
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
K1 Breast cancer
K1 Prostate cancer
K1 Case-cohort
K1 Bisphenol a
K1 Environmental pollutants
K1 Endocrine disruptors
K1 Neoplasias de la mama
K1 Neoplasias de la próstata
K1 Estudios de cohortes
K1 Bisfenol A glicidil metacrilato
K1 Contaminantes ambientales
K1 Disruptores endocrinos
AB BackgroundBisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. The aim of this study was to assess the potential association of serum BPA concentrations and the risk of incident breast and prostate cancer in a sub-cohort of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsWe designed a case-cohort study within the EPIC-Spain cohort. Study population consisted on 4812 participants from 4 EPIC-Spain centers (547 breast cancer cases, 575 prostate cancer cases and 3690 sub-cohort participants). BPA exposure was assessed by means of chemical analyses of serum samples collected at recruitment. Borgan II weighted Cox regression was used to estimate hazard ratios.ResultsMedian follow-up time in our study was 16.9 years. BPA geometric mean serum values of cases and sub-cohort were 1.12 ng/ml vs 1.10 ng/ml respectively for breast cancer and 1.33 ng/ml vs 1.29 ng/ml respectively for prostate cancer. When categorizing BPA into tertiles, a 40% increase in risk of prostate cancer for tertile 1 (p = 0.022), 37% increase for tertile 2 (p = 0.034) and 31% increase for tertile 3 (p = 0.072) was observed with respect to values bellow the limit of detection. No significant association was observed between BPA levels and breast cancer risk.ConclusionsWe found a similar percentage of detection of BPA among cases and sub-cohort from our population, and no association with breast cancer risk was observed. However, we found a higher risk of prostate cancer for the increase in serum BPA levels. Further investigation is needed to understand the influence of BPA in prostate cancer risk.
PB BioMed Central, Springer Nature
YR 2021
FD 2021-08-16
LK http://hdl.handle.net/10668/4435
UL http://hdl.handle.net/10668/4435
LA en
NO Salamanca-Fernández E, Rodríguez-Barranco M, Amiano P, Delfrade J, Chirlaque MD, Colorado S, et al. Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study. Environ Health. 2021 Aug 16;20(1):88
DS RISalud
RD Apr 5, 2025