RT Journal Article
T1 Impact of late presentation of HIV infection on short-, mid- and long-term mortality and causes of death in a multicenter national cohort: 2004-2013.
A1 Sobrino-Vegas, Paz
A1 Moreno, Santiago
A1 Rubio, Rafael
A1 Viciana, Pompeyo
A1 Bernardino, José Ignacio
A1 Blanco, José Ramón
A1 Bernal, Enrique
A1 Asensi, Víctor
A1 Pulido, Federico
A1 del Amo, Julia
A1 Hernando, Victoria
A1 Cohorte de la Red de Investigación en Sida, Spain
K1 Causes of death
K1 Cohort study
K1 Factors and trends
K1 HIV
K1 Late presentation
K1 Mortality
AB To analyze the impact of late presentation (LP) on overall mortality and causes of death and describe LP trends and risk factors (2004-2013). Cox models and logistic regression were used to analyze data from a nation-wide cohort in Spain. LP is defined as being diagnosed when CD4  Of 7165 new HIV diagnoses, 46.9% (CI95%:45.7-48.0) were LP, 240 patients died. First-year mortality was the highest (aHRLP.vs.nLP = 10.3[CI95%:5.5-19.3]); between 1 and 4 years post-diagnosis, aHRLP.vs.nLP = 1.9(1.2-3.0); and >4 years, aHRLP.vs.nLP = 1.5(0.7-3.1). First-year's main cause of death was HIV/AIDS (73%); and malignancies among those surviving >4 years (32%). HIV/AIDS-related deaths were more likely in LP (59.2% vs. 25.0%; p 4 years, aHRLP.vs.nLP = 1.5(0.7-3.1). First-year's main cause of death was HIV/AIDS (73%); and malignancies among those surviving >4 years (32%). HIV/AIDS-related deaths were more likely in LP (59.2% vs. 25.0%; p 4 years (32%). HIV/AIDS-related deaths were more likely in LP (59.2% vs. 25.0%; p 50.vs. LP is associated with higher mortality, especially short-term- and HIV/AIDS-related mortality. Mid-term-, but not long-term mortality, remained also higher in LP than nLP. LP decreased in MSM and heterosexual men, not in heterosexual women. The groups most affected by LP are low educated, non-Spanish and heterosexual women.
YR 2016
FD 2016-02-24
LK http://hdl.handle.net/10668/9875
UL http://hdl.handle.net/10668/9875
LA en
DS RISalud
RD Apr 6, 2025