RT Journal Article
T1 Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients.
A1 Araos, Pedro
A1 Vidal, Rebeca
A1 O'Shea, Esther
A1 Pedraz, María
A1 García-Marchena, Nuria
A1 Serrano, Antonia
A1 Suárez, Juan
A1 Castilla-Ortega, Estela
A1 Ruiz, Juan Jesús
A1 Campos-Cloute, Rafael
A1 Santín, Luis J
A1 Rodríguez de Fonseca, Fernando
A1 Pavón, Francisco Javier
A1 Colado, María Isabel
AB The lack of effective treatments and a high rate of relapse in cocaine addiction constitute a major health problem. The present study was conducted to examine the expression of tryptophan-derived metabolites in the context of cocaine addiction and psychiatric comorbidity, which is common in addicted subjects. Abstinent patients with cocaine use disorder (CUD) and control subjects were recruited for a cross-sectional study. Participants were assessed with a semi-structured diagnostic interview (PRISM) based on DSM-IV-TR for substance and mental disorders. Plasma concentrations of tryptophan metabolites and their association with relevant CUD-related variables and psychiatric comorbidity were explored. We observed decreased plasma kynurenic acid concentrations in the cocaine group, however no associations between CUD-related variables and tryptophan-derived metabolites were found. In contrast, 5-HT concentrations were increased in CUD-patients and the diagnosis of different psychiatric disorders in the cocaine group was related to higher plasma 5-HT concentrations compared with non-comorbid patients. Therefore, while changes in plasma kynurenic acid concentrations appear to be directly associated with lifetime CUD, changes in 5-HT concentrations are associated with psychiatric comorbidity. These results emphasize the need to find potential biomarkers for a better stratification of cocaine-addicted patients in order to develop therapeutic approaches to prevent cocaine relapse.
YR 2019
FD 2019-11-14
LK http://hdl.handle.net/10668/14691
UL http://hdl.handle.net/10668/14691
LA en
DS RISalud
RD Apr 8, 2025