RT Journal Article
T1 New diagnosis of mother-to-child transmission of HIV in 8 Latin-American countries during 2018.
A1 Hernanz-Lobo, Alicia
A1 Ruiz Saez, Beatriz
A1 Carrasco García, Itziar
A1 Mino-Leon, Greta
A1 Juárez, Julio
A1 Pavía Ruz, Noris
A1 Estripeaut, Dora
A1 Pérez, María de Los Ángeles
A1 Erazo, Karen
A1 Castaneda Villatoro, Luis Guillermo
A1 Porras, Oscar
A1 Prieto Tato, Luis Manuel
A1 Navarro Gómez, María Luisa
A1 CYTED PLANTAIDS group, 
K1 HIV
K1 Infectious disease transmission, vertical
K1 Pregnant women
AB Important prevention efforts have led to a reduction in mother-to-child transmission of HIV (MTCT) globally. However, new cases of paediatric HIV infections still occur. Early diagnosis of new HIV infections is essential to start an appropriate antiretroviral treatment to avoid childhood morbidity and mortality related to infection. The aim of this study was to describe the new cases of MTCT in Latin-American referral hospitals. A retrospective, multicentre and descriptive study of the new cases of MTCT diagnosed during 2018 in 13 referral hospitals from 8 Latin-American countries (Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, and Panama) belonging to PLANTAIDS (Paediatric Network for Prevention, Early Detection and Treatment of HIV in Children), was conducted. PLANTAIDS is included in CYTED (Ibero-American Programme of Science and Technology for Development). Eighty-one children (40.7% males) were included, median age at diagnosis of 2.33 years (IQR:0.7-4.7). Less than 3% of women knew their HIV diagnosis before pregnancy. More than 80% of them were diagnosed after delivery, 8.7% during pregnancy, and 2.9% at delivery. Only one patient underwent antiretroviral therapy (ART) prior to pregnancy. At diagnosis, 50.0% of the children presented with an advanced stage of disease (stage C following the current CDC classification for HIV infection), and 34.4% had less than 15% CD4+ cells/mm3. The time elapsed between delivery and the maternal diagnosis was correlated with the age of children at diagnosis, ρ = 0.760, p  Although MTCT in Latin America has declined in recent years, our series shows there are still cases that indicate some failures in prevention, being a critical point to improve an earlier diagnosis of pregnant women. Half of the children were diagnosed in an advanced stage of disease and the delay in maternal diagnosis entailed a worse clinical and immunological child' prognosis.
YR 2022
FD 2022-04-07
LK http://hdl.handle.net/10668/20269
UL http://hdl.handle.net/10668/20269
LA en
DS RISalud
RD Apr 11, 2025