RT Journal Article
T1 Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells.
A1 Álvarez-Palomo, Belén
A1 García-Martinez, Iris
A1 Gayoso, Jorge
A1 Raya, Angel
A1 Veiga, Anna
A1 Abad, María Luisa
A1 Eiras, Adolfo
A1 Guzmán-Fulgencio, María
A1 Luis-Hidalgo, Mar
A1 Eguizabal, Cristina
A1 Santos, Silvia
A1 Balas, Antonio
A1 Alenda, Raquel
A1 Sanchez-Gordo, Francisco
A1 Verdugo, Laura Ponce
A1 Villa, Juliana
A1 Carreras, Enric
A1 Vidal, Francisco
A1 Madrigal, Alejandro
A1 Herrero, María José
A1 Rudilla, Francesc
A1 Querol, Sergi
K1 HLA matching
K1 Haplobank
K1 Homozygous
K1 Induced pluripotent stem cells
AB iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation of iPSC derived cell therapies. Cord blood banks offer an extensive source of HLA-typed cells suitable for reprogramming to iPSC. Several initiatives worldwide have been undertaken to create national and international iPSC haplobanks that match a significant part of a population. To create an iPSC haplobank that serves the Spanish population (IPS-PANIA), we have searched the Spanish Bone Marrow Donor Registry (REDMO) to identify the most frequently estimated haplotypes. From the top ten donors identified, we estimated the population coverage using the criteria of zero mismatches in HLA-A, HLA-B, and HLA-DRB1 with different stringencies: high resolution, low resolution, and beneficial mismatch. We have calculated that ten cord blood units from homozygous donors stored at the Spanish cord blood banks can provide HLA-A, HLA-B, and HLA-DRB1 matching for 28.23% of the population. We confirm the feasibility of using banked cord blood units to create an iPSC haplobank that will cover a significant percentage of the Spanish and international population for future advanced therapy replacement strategies.
YR 2021
FD 2021-04-13
LK http://hdl.handle.net/10668/17572
UL http://hdl.handle.net/10668/17572
LA en
DS RISalud
RD Apr 18, 2025