RT Journal Article
T1 Glycodendropeptides stimulate dendritic cell maturation and T cell proliferation: a potential influenza A virus immunotherapy
A1 Mascaraque, Ainhoa
A1 Kowalczyk, Wioleta
A1 Fernández, Tahia
A1 Palomares, Francisca
A1 Mayorga, Cristobalina
A1 Andreu, David
A1 Rojo, Javier
K1 Moléculas de adhesión celular
K1 Química clic
K1 Secuencia conservada
K1 Dendrímeros
K1 Células dendríticas
K1 Epítopos
K1 Inmunoterapia
K1 Lectinas tipo C
K1 Manosa
K1 Lectinas de unión a manosa
K1 Péptidos
K1 Proteínas de unión al ARN
K1 Receptores de superficie celular
K1 Linfocitos T
K1 Vacunas
K1 Proteínas del centro vírico
AB Mannosylation facilitates uptake and internalization of immunogenic peptides by antigen-processing cells expressing mannose receptors at their surface, such as DC-SIGN, a lectin that plays a key role in the immune response against different pathogens. This internalization, processing and subsequent MHC presentation may result in a strong T cell stimulation. Here, we hypothesized that combining mannose glycodendrons with multivalent presentation of peptide epitopes in a likewise dendron format would yieldhybrid constructs, named glycodendropeptides (GDPs), with the capacity to enhance peptide immunogenicity, hence providing a novel and versatile platform for applications in immunotherapy. Thus, GDPs of differentvalencies displaying the NP366–374 epitope, a conserved sequence from the influenza A virus nucleoprotein (NP), have been built by two click chemistry-based methodologies and assessed as potential flu vaccine candidates. Preliminary evaluation of the ability of these constructs to stimulate dendritic cell maturation and lymphocyte proliferation was promising, showing the highest-functionalized NP366–374 GDPs as inducing the strongest immunostimulatory effect.
PB Royal Society of Chemistry
SN 2040-2511
YR 2015
FD 2015-10
LK http://hdl.handle.net/10668/2274
UL http://hdl.handle.net/10668/2274
LA en
NO Masqueraque A, Kowalczyk V, Fernández T. Palomares F,Mayorga C, Andreu D. Glycodendropeptides stimulate dendritic cell maturtion and T cell proliferation: a potential influenza  A virus immunotherapy. MedChemComm. 2015; 6. 1755-1760.
DS RISalud
RD Apr 6, 2025