RT Journal Article
T1 Glycodendropeptides stimulate dendritic cell maturation and T cell proliferation: a potential influenza A virus immunotherapy
A1 Mascaraque, Ainhoa
A1 Kowalczyk, Wioleta
A1 Fernández, Tahia
A1 Palomares, Francisca
A1 Mayorga, Cristobalina
A1 Andreu, David
A1 Rojo, Javier
K1 Mannose Receptor
K1 Antigen-Presenting Cells
K1 Dendritic Cells
K1 Immunogenic Peptides
K1 Immune Response
K1 Influenza Virus
AB Mannosylation facilitates uptake and internalization of immunogenic peptides by antigen-processing cells expressing mannose receptors at their surface, such as DC-SIGN, a lectin that plays a key role in the immune response against different pathogens. This internalization, processing and subsequent MHC presentation may result in a strong T cell stimulation. Here, we hypothesized that combining mannose glycodendrons with multivalent presentation of peptide epitopes in a likewise dendron format would yield hybrid constructs, named glycodendropeptides (GDPs), with the capacity to enhance peptide immunogenicity, hence providing a novel and versatile platform for applications in immunotherapy. Thus, GDPs of different valencies displaying the NP366–374 epitope, a conserved sequence from the influenza A virus nucleoprotein (NP), have been built by two click chemistry-based methodologies and assessed as potential flu vaccine candidates. Preliminary evaluation of the ability of these constructs to stimulate dendritic cell maturation and lymphocyte proliferation was promising, showing the highest-functionalized NP366–374 GDPs as inducing the strongest immunostimulatory effect.
PB Royal Society of Chemistry
SN 2040-2511
YR 2015
FD 2015-10
LK http://hdl.handle.net/10668/2274
UL http://hdl.handle.net/10668/2274
LA en
NO Masqueraque A, Kowalczyk V, Fernández T. Palomares F,Mayorga C, Andreu D. Glycodendropeptides stimulate dendritic cell maturtion and T cell proliferation: a potential influenza  A virus immunotherapy. MedChemComm. 2015; 6. 1755-1760.
DS RISalud
RD Sep 17, 2025