RT Journal Article
T1 The role of the FTO gene in the relationship between depression and obesity. A systematic review.
A1 Zarza-Rebollo, Juan Antonio
A1 Molina, Esther
A1 Rivera, Margarita
K1 BMI
K1 Depression
K1 FTO
K1 Obesity
K1 rs9939609
AB Depression and obesity are major global health problems that frequently co-occur. The FTO gene has one of the strongest links with obesity and high body mass index (BMI) in humans. Besides, this gene is highly expressed in the brain, may play a role in the nervous system, and could confer risk for depression, although scarce literature is available in this respect. We perform a systematic review of the relationship between FTO and both conditions. We selected original articles with observational design or reviews, where depression was assessed with ICD-10, DSM-5 or previous versions, published from 2012 (when the first related paper was published) to November 2020, performed in adults, in English or Spanish and having an optimal methodological quality (evaluated with SIGN checklist). Five original studies were finally included. The results regarding the role of FTO in depression-obesity comorbidity were inconclusive. This leads us to endorse further research covering the role of this gene on both conditions, emphasising a more precise characterization of depression, in order to confirm this role.
YR 2021
FD 2021-05-19
LK https://hdl.handle.net/10668/24777
UL https://hdl.handle.net/10668/24777
LA en
DS RISalud
RD Apr 18, 2025