RT Journal Article
T1 Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study.
A1 Abuin-Fernandez, Jose
A1 Tapia-Guerrero, Maria Jose
A1 Lopez-Urdiales, Rafael
A1 Herranz-Antolin, Sandra
A1 Garcia-Almeida, Jose Manuel
A1 Garcia-Malpartida, Katherine
A1 Ferrer-Gomez, Mercedes
A1 Cancer-Minchot, Emilia
A1 Luengo-Perez, Luis Miguel
A1 Alvarez-Hernandez, Julia
A1 Valera, Carmen Aragon
A1 Ocon-Breton, Julia
A1 Garcia-Manzanares, Alvaro
A1 Breton-Lesmes, Irene
A1 Serrano-Aguayo, Pilar
A1 Perez-Ferre, Natalia
A1 Lopez-Gomez, Juan Jose
A1 Olivares-Alcolea, Josefina
A1 Arraiza-Irigoyen, Carmen
A1 Tejera-Perez, Cristina
A1 Martinez-Gonzalez, Jorge Daniel
A1 Urioste-Fondo, Ana
A1 Abad-Gonzalez, Angel Luis
A1 Molina-Puerta, Maria Jose
A1 Zugasti-Murillo, Ana
A1 Parra-Barona, Juan
A1 Lopez-Cobo, Irela
A1 Olveira-Fuster, And Gabriel
K1 hospital
K1 omega 3
K1 parenteral nutrition
K1 polyunsaturated fatty acids
K1 type 2 diabetes mellitus
AB There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.
PB MDPI AG
YR 2020
FD 2020-05-25
LK http://hdl.handle.net/10668/15660
UL http://hdl.handle.net/10668/15660
LA en
NO Abuín-Fernández J, Tapia-Guerrero MJ, López-Urdiales R, Herranz-Antolín S, García-Almeida JM, García-Malpartida K, et al. Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study. Nutrients. 2020 May 27;12(6):1566. doi: 10.3390/nu12061566.
DS RISalud
RD Apr 6, 2025