RT Journal Article
T1 Association of menopausal characteristics and risk of coronary heart disease: a pan-European case-cohort analysis.
A1 Dam, Veerle
A1 van der Schouw, Yvonne T
A1 Onland-Moret, N Charlotte
A1 Groenwold, Rolf H H
A1 Peters, Sanne A E
A1 Burgess, Stephen
A1 Wood, Angela M
A1 Chirlaque, Maria-Dolores
A1 Moons, Karel G M
A1 Oliver-Williams, Clare
A1 Schuit, Ewoud
A1 Tikk, Kaja
A1 Weiderpass, Elisabete
A1 Holm, Marianne
A1 Tjønneland, Anne
A1 Kühn, Tilman
A1 Fortner, Renée T
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 La Vecchia, Carlo
A1 Ferrari, Pietro
A1 Gunter, Marc
A1 Masala, Giovanna
A1 Sieri, Sabina
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Boer, Jolanda M A
A1 Verschuren, W M Monique
A1 Salamanca-Fernández, Elena
A1 Arriola, Larraitz
A1 Moreno-Iribas, Conchi
A1 Engström, Gunnar
A1 Melander, Olle
A1 Nordendahl, Maria
A1 Wennberg, Patrik
A1 Key, Timothy J
A1 Colorado-Yohar, Sandra
A1 Matullo, Giuseppe
A1 Overvad, Kim
A1 Clavel-Chapelon, Francoise
A1 Boeing, Heiner
A1 Quiros, J Ramon
A1 di Angelantonio, Emanuele
A1 Langenberg, Claudia
A1 Sweeting, Michael J
A1 Riboli, Elio
A1 Wareham, Nicholas J
A1 Danesh, John
A1 Butterworth, Adam
K1 Epidemiology
K1 Menopause
K1 ageing
K1 coronary disease
K1 risk factors
K1 women
AB Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these associations are explained by established cardiovascular risk factors. We used data from EPIC-CVD, a case-cohort study, which includes data from 23 centres from 10 European countries. We included only women, of whom 10 880 comprise the randomly selected sub-cohort, supplemented with 4522 cases outside the sub-cohort. We conducted Prentice-weighted Cox proportional hazards regressions with age as the underlying time scale, stratified by country and adjusted for relevant confounders. After confounder and intermediate adjustment, post-menopausal women were not at higher CHD risk compared with pre-menopausal women. Among post-menopausal women, earlier menopause was linearly associated with higher CHD risk [HRconfounder and intermediate adjusted per-year decrease = 1.02, 95% confidence interval (CI) = 1.01-1.03, p = 0.001]. Women with a surgical menopause were at higher risk of CHD compared with those with natural menopause (HRconfounder-adjusted = 1.25, 95% CI = 1.10-1.42, p  Earlier and surgical menopause were associated with higher CHD risk. These associations could partially be explained by differences in conventional cardiovascular risk factors. These women might benefit from close monitoring of cardiovascular risk factors and disease.
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13616
UL http://hdl.handle.net/10668/13616
LA en
DS RISalud
RD Apr 7, 2025