TY  - JOUR
AU  - Bermudez-Silva, Francisco J
AU  - Romero-Zerbo, Silvana Y
AU  - Haissaguerre, Magalie
AU  - Ruz-Maldonado, Inmaculada
AU  - Lhamyani, Said
AU  - El Bekay, Rajaa
AU  - Tabarin, Antoine
AU  - Marsicano, Giovanni
AU  - Cota, Daniela
PY  - 2016
DO  - 10.1242/dmm.020750
SN  - 1754-8403
UR  - http://hdl.handle.net/10668/2431
T2  - Disease Models & Mechanisms
AB  - The endocannabinoid system (ECS) is an intercellular signalling mechanism that is present in the islets of Langerhans and plays a role in the modulation of insulin secretion and expansion of the β-cell mass. The downstream signalling pathways...
LA  - en
PB  - The Company of Biologists
KW  - Cannabinoids
KW  - Insulin secrection
KW  - Rapamycin
KW  - Rimonabant
KW  - Islets
KW  - CB1
KW  - S6K1
KW  - Animales
KW  - Inmunotransferencia Western
KW  - Peso corporal
KW  - Endocannabinoides
KW  - Glucosa
KW  - Intolerancia a la glucosa
KW  - Homeostasis
KW  - Resistencia a la insulina
KW  - Células secretoras de insulina
KW  - Insulinas
KW  - Islotes pancreáticos
KW  - Ratones
KW  - Complejos multiproteicos
KW  - Fosforilación
KW  - Piperidinas
KW  - Pirazoles
KW  - Receptor cannabinoide CB1
KW  - Proteína S6 ribosómica
KW  - Sirolimus
KW  - TOR serina-treonina cinasas
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Electrophoresis::Blotting, Western
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Size::Body Weight
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Endocannabinoids
KW  - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperglycemia::Glucose Intolerance
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Insulin Resistance
KW  - Medical Subject Headings::Anatomy::Cells::Endocrine Cells::Enteroendocrine Cells::Insulin-Secreting Cells
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulins
KW  - Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Multiprotein Complexes
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrazoles
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB1
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Ribosomal Proteins::Ribosomal Protein S6
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Sirolimus
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::TOR Serine-Threonine Kinases
TI  - The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.
TY  - research article
ER  -