RT Journal Article
T1 Influence of a fat overload on lipogenic regulators in metabolic syndrome patients
A1 Mayas Torres, María Dolores
A1 Queipo-Ortuño, María Isabel
A1 Clemente-Postigo, Mercedes
A1 Macías González, Manuel
A1 El Bekay, Rajaa
A1 Tinahones, Francisco J
A1 Cardona Díaz, Fernando
K1 Complejo Ácido Graso Sintetasa
K1 Femenino
K1 Humanos
K1 Leucocitos Mononucleares
K1 Peróxidos Lipídicos
K1 Lipogénesis
K1 Masculino
K1 Síndrome X Metabólico
K1 Receptores Nucleares Huérfanos
K1 ARN Mensajero
K1 Receptores X Retinoide
K1 Proteínas de Unión a los Elementos Reguladores de Esteroles
K1 Triglicéridos
K1 Grasas en la Dieta
K1 Genetic expression
K1 Postprandial hypertriacylglycerolaemia
K1 Lipogenic genes
AB Several epidemiological studies have related an increase of lipids in the postprandial state to an individual risk for the development of CVD, possibly due to the increased plasma levels of TAG and fatty acids (FA) through enzymes of FA metabolism. The interaction between nutrition and the human genome determines gene expression and metabolic response. The aim of the present study was to evaluate the influence of a fat overload on the gene mRNA levels of lipogenic regulators in peripheral blood mononuclear cells (PBMC) from patients with the metabolic syndrome. The study included twenty-one patients with criteria for the metabolic syndrome who underwent a fat overload. Measurements were made before and after the fat overload of anthropometric and biochemical variables and also the gene mRNA levels of lipogenic factors. The main results were that the fat overload led to an increased mRNA levels of sterol regulatory element binding protein-1 (SREBP1), retinoid X receptor α (RXRα) and liver X receptor α (LXRα) in PBMC, and this increase was associated with the FA synthase (FASN) mRNA levels. We also found that TAG levels correlated with FASN mRNA levels. In addition, there was a positive correlation of SREBP1 with RXRα and of LXRα with the plasma lipoperoxide concentration. The fat overload led to an increase in regulators of lipogenesis in PBMC from patients with the metabolic syndrome.
PB Cambridge University Press
SN 0007-1145
YR 2011
FD 2011-03
LK http://hdl.handle.net/10668/846
UL http://hdl.handle.net/10668/846
LA en
NO Mayas MD, Queipo-Ortuño MI, Clemente-Postigo M, Macias M, El Bekay R, Tinahones FJ, Cardona F. Influence of a fat overload on lipogenic regulators in metabolic syndrome patients. Br. J. Nutr.. 2011; 105(6):895-901
NO Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 7, 2025