TY - JOUR AU - Herraiz-Martínez, Adela AU - Llach, Anna AU - Tarifa, Carmen AU - Gandía, Jorge AU - Jiménez-Sabado, Verónica AU - Lozano-Velasco, Estefanía AU - Serra, Selma A AU - Vallmitjana, Alexander AU - Vázquez Ruiz de Castroviejo, Eduardo AU - Benítez, Raúl AU - Aranega, Amelia AU - Muñoz-Guijosa, Christian AU - Franco, Diego AU - Cinca, Juan AU - Hove-Madsen, Leif PY - 2019 DO - 10.1093/cvr/cvy215 UR - http://hdl.handle.net/10668/12952 T2 - Cardiovascular research AB - Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers their... LA - en KW - Human atrial myocytes KW - Ryanodine receptor KW - Sarcoplasmic reticulum calcium release KW - Single nucleotide polymorphisms KW - Spontaneous electrical activity KW - Action Potentials KW - Aged KW - Atrial Fibrillation KW - Calcium KW - Calcium Signaling KW - Case-Control Studies KW - Chromosomes, Human, Pair 4 KW - Female KW - Genetic Association Studies KW - Genetic Predisposition to Disease KW - Heart Atria KW - Heart Rate KW - Homeostasis KW - Humans KW - Male KW - Myocytes, Cardiac KW - Phenotype KW - Phosphorylation KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Ryanodine Receptor Calcium Release Channel KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases TI - The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis. TY - research article VL - 115 ER -