TY - JOUR AU - Maya Miles, Douglas AU - Peñate, Xenia AU - Sanmartín Olmo, Trinidad AU - Jourquin, Frederic AU - Muñoz Centeno, Maria Cruz AU - Mendoza, Manuel AU - Simon, Marie-Noelle AU - Chavez, Sebastian AU - Geli, Vincent PY - 2018 DO - 10.7554/eLife.35337 UR - https://hdl.handle.net/10668/27856 T2 - eLife AB - Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are... LA - en KW - chromosomes KW - genes KW - histones KW - CDC28 Protein Kinase, S cerevisiae KW - Cell Cycle Proteins KW - Chromosome Duplication KW - Histones KW - Phosphorylation KW - Protein Processing, Post-Translational KW - Protein-Tyrosine Kinases KW - Saccharomyces cerevisiae KW - Saccharomyces cerevisiae Proteins TI - High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1. TY - research article VL - 7 ER -