RT Journal Article
T1 High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1.
A1 Maya Miles, Douglas
A1 Peñate, Xenia
A1 Sanmartín Olmo, Trinidad
A1 Jourquin, Frederic
A1 Muñoz Centeno, Maria Cruz
A1 Mendoza, Manuel
A1 Simon, Marie-Noelle
A1 Chavez, Sebastian
A1 Geli, Vincent
K1 chromosomes
K1 genes
K1 histones
AB Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to a reduced incorporation of the histone variant H2A.Z to chromatin. Moreover, we show that high levels of histones promote Swe1WEE1 stabilisation thereby triggering the phosphorylation and inhibition of Cdc28CDK1 through a mechanism different of the canonical DNA damage response. Our results link high levels of histones to a specific type of genome instability that is quite frequently observed in cancer and uncovers a new mechanism that might be able to respond to high levels of histones.
YR 2018
FD 2018-03-27
LK https://hdl.handle.net/10668/27856
UL https://hdl.handle.net/10668/27856
LA en
DS RISalud
RD Apr 12, 2025