RT Journal Article
T1 Neuropsychiatric Symptoms in Clinically Defined Parkinson's Disease: An Updated Review of Literature.
A1 Macias-Garcia, Paloma
A1 Rashid-Lopez, Raul
A1 Cruz-Gomez, Alvaro J
A1 Lozano-Soto, Elena
A1 Sanmartino, Florencia
A1 Espinosa-Rosso, Raul
A1 Gonzalez-Rosa, Javier J
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
K1 Disruptive
K1 Impulse control
K1 Conduct disorders
AB Neuropsychiatric symptoms (NPS) are a common and potentially serious manifestation of Parkinson's disease (PD) but are frequently overlooked in favor of a focus on motor symptomatology. Here, we conducted a literature review of the prevalence and type of NPS experienced by PD patients with a clinically defined course of their illness. We identified reports of NPS in patients with PD and mean disease duration over 3 years. Three databases-PubMed, Scopus, and Dialnet-were searched for relevant literature published between 2010 and 2020. Predefined exclusion criteria were applied prior to a descriptive analysis of the literature base. In all, 87 unique reports were identified and 30 met inclusion and exclusion criteria. These included 7142 patients with PD (male: 67.3%; mean age: 66.2 years; mean disease duration: 6.7 years). The most frequent NPS were mood disorders (apathy, depression, and anxiety), psychosis, and impulse control disorders (ICD). Treatment with dopamine agonists was identified as an important risk factor for ICD. Co-occurrence of NPS and cognitive dysfunction was also evidenced in a number of studies. Patients with more significant cognitive deficits and higher levels of NPS appeared to be of older age with a longer disease duration and to have more severe motor symptoms. NPS, most commonly mood disorders (apathy, depression, and anxiety), psychosis, and ICDs are frequent manifestations of PD. The results of this review reflect the need to develop unified validated assessment protocols for NPS in PD, as well as to improve their management in clinical practice.
PB Wiley
YR 2022
FD 2022-03-09
LK http://hdl.handle.net/10668/20172
UL http://hdl.handle.net/10668/20172
LA en
NO Macías-García P, Rashid-López R, Cruz-Gómez ÁJ, Lozano-Soto E, Sanmartino F, Espinosa-Rosso R, et al. Neuropsychiatric Symptoms in Clinically Defined Parkinson's Disease: An Updated Review of Literature. Behav Neurol. 2022 May 9;2022:1213393
NO This work has been supported by the Spanish Ministry of Science, Innovation and Universities (MICINN) under grant (PSI2017-85951-R) and by the European Regional Development Fund through the Andalusian Ministry of Health and Families under grants (PI-0025-2017; PI-0034-2019).
DS RISalud
RD Apr 18, 2025