RT Journal Article
T1 Functional Effects of the Buckwheat Iminosugar d-Fagomine on Rats with Diet-Induced Prediabetes.
A1 Ramos-Romero, Sara
A1 Hereu, Mercè
A1 Atienza, Lidia
A1 Casas, Josefina
A1 Taltavull, Núria
A1 Romeu, Marta
A1 Amézqueta, Susana
A1 Dasilva, Gabriel
A1 Medina, Isabel
A1 Torres, Josep L
K1 diabetes
K1 iminocyclitol
K1 iminosugars
K1 inflammation
K1 microbiota
K1 obesity
AB The goals of this work are to test if d-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. Wistar Kyoto rats were fed a high-fat diet supplemented with d-fagomine (or not, for comparison) or a standard diet (controls) for 24 weeks. The variables measured were fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue (AT), liver, and muscle; inflammation markers (plasma IL-6 and leptin, and liver and AT histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales, and Bifidobacteriales in feces. It was found that d-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers, and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 , and leukotriene B4 ) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales. d-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of d-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria.
YR 2018
FD 2018-08-01
LK http://hdl.handle.net/10668/12686
UL http://hdl.handle.net/10668/12686
LA en
DS RISalud
RD Apr 9, 2025