RT Journal Article
T1 A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children.
A1 Gomez-Llorente, Mª Amelia
A1 Martínez-Cañavate, Ana
A1 Chueca, Natalia
A1 Rico, Mª de la Cruz
A1 Romero, Raquel
A1 Anguita-Ruiz, Augusto
A1 Aguilera, Concepción Mª
A1 Gil-Campos, Mercedes
A1 Mesa, Maria D
A1 Khakimov, Bekzod
A1 Morillo, Jose Antonio
A1 Gil, Ángel
A1 Camacho, José
A1 Gomez-Llorente, Carolina
K1 asthma
K1 gastrointestinal microbiome
K1 metabolomics
K1 multi-omics approach
AB Background: Asthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota signatures that characterize the clinical allergic asthma phenotype in obese children. Methods: We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers, metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover, allergic children with a worse asthma outcome showed higher levels of large unstained cells, fecal D lactate and D/L lactate ratio, and with a higher relative proportion of plasma creatinine and an unclassified family member from the RF39 order belonging to the Mollicutes class. Otherwise, children with persistent asthma presented lower levels of plasma citrate and dimethylsulfone. Conclusion: Our integrative approach shows the molecular heterogeneity of the allergic asthma phenotype while highlighting the use of omics technologies to examine the clinical phenotype at a more holistic level.
SN 2227-9059
YR 2020
FD 2020-09-18
LK https://hdl.handle.net/10668/24786
UL https://hdl.handle.net/10668/24786
LA en
DS RISalud
RD Apr 7, 2025