RT Journal Article
T1 Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects.
A1 Moreno, María
A1 Moreno-Navarrete, José María
A1 Serrano, Marta
A1 Ortega, Francisco
A1 Delgado, Elías
A1 Sanchez-Ragnarsson, Cecilia
A1 Valdés, Sergio
A1 Botas, Patricia
A1 Ricart, Wifredo
A1 Fernández-Real, José Manuel
K1 Enfermedades cardiovasculares
K1 Diabetes mellitus tipo II
K1 Fibronectinas
K1 Resistencia a la insulina
K1 Estudios prospectivos
K1 Factores de riesgo
K1 Población rural
K1 Vida sedentaria
AB INTRODUCTIONA physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels in association with the degree of physical activity and various metabolic parameters in humans.METHODSCirculating irisin levels (ELISA) and metabolic parameters were analyzed in 428 subjects (195 men/233 women). Participants were classified according to their self-reported physical activity and to their area of residence.RESULTSCirculating irisin levels were higher in active than in sedentary subjects (p = 0.006). Rural inhabitants showed higher circulating irisin levels than urban subjects (p < 0.0001). The increase in irisin levels related to an active lifestyle was only observed in rural citizens (p = 0.014). Among sedentary participants, irisin levels were positively associated with metabolic risk factors (BMI, fasting insulin, HOMA and fasting triglycerides). The area of residence (β = - 0.592, p = < 0.0001) contributed independently to circulating irisin levels variance after controlling for age, gender, BMI, HOMAIR, triglycerides and physical activity.CONCLUSIONSIn sedentary participants, circulating irisin levels were positively associated with parameters related to an increased cardiometabolic risk. The present study confirmed that an active lifestyle increases circulating irisin levels, but only among subjects living in a rural environment. Area of residence might be a determinant of irisin levels.
PB Public Library of Science
YR 2015
FD 2015-04-21
LK http://hdl.handle.net/10668/2328
UL http://hdl.handle.net/10668/2328
LA en
NO Moreno M, Moreno-Navarrete JM, Serrano M, Ortega F, Delgado E, Sanchez-Ragnarsson C, et al. Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. PLoS ONE. 2015; 10(4):e0124100
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 9, 2025