RT Journal Article
T1 Concurrent Assessment of Phthalates/HEXAMOLL® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies.
A1 Rosolen, Valentina
A1 Giordani, Elisa
A1 Mariuz, Marika
A1 Parpinel, Maria
A1 Ronfani, Luca
A1 Vecchi Brumatti, Liza
A1 Bin, Maura
A1 Calamandrei, Gemma
A1 Mustieles, Vicente
A1 Gilles, Liese
A1 Govarts, Eva
A1 Baken, Kirsten
A1 Rodriguez Martin, Laura
A1 Schoeters, Greet
A1 Sepai, Ovnair
A1 Sovcikova, Eva
A1 Fabelova, Lucia
A1 Sidlovska, Miroslava
A1 Kolena, Branislav
A1 Kold Jensen, Tina
A1 Frederiksen, Hanne
A1 Kolossa-Gehring, Marike
A1 Lange, Rosa
A1 Apel, Petra
A1 Castano, Argelia
A1 Esteban Lopez, Marta
A1 Jacobs, Griet
A1 Voorspoels, Stefan
A1 Jurdakova, Helena
A1 Gorova, Renata
A1 Barbone, Fabio
K1 Full-Scale Intelligence Quotient
K1 HBM4EU
K1 HEXAMOLL® DINCH
K1 WISC
K1 aligned studies
K1 children
K1 environmental contaminants
K1 human biomonitoring
K1 neurodevelopment
K1 phthalates
AB Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL® DINCH) on children's neurodevelopment is limited. The aim of the present research is to evaluate the association between phthalate/HEXAMOLL® DINCH exposure and child neurodevelopment in three European cohorts involved in HBM4EU Aligned Studies. Participating subjects were school-aged children belonging to the Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, and PCB cohort, Slovakia. In each cohort, children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score (FSIQ) of the Wechsler Intelligence Scale of Children test using three different editions. The children's urine samples, collected for one point in time concurrently with the neurodevelopmental evaluation, were analyzed for several phthalates/HEXAMOLL® DINCH biomarkers. The relation between phthalates/HEXAMOLL® DINCH and FSIQ was explored by applying separate multiple linear regressions in each cohort. The means and standard deviations of FSIQ were 109 ± 11 (NAC-II), 98 ± 12 (OCC), and 81 ± 15 (PCB cohort). In NAC-II, direct associations between FSIQ and DEHP's biomarkers were found: 5OH-MEHP+5oxo-MEHP (β = 2.56; 95% CI 0.58-4.55; N = 270), 5OH-MEHP+5cx-MEPP (β = 2.48; 95% CI 0.47-4.49; N = 270) and 5OH-MEHP (β = 2.58; 95% CI 0.65-4.51; N = 270). On the contrary, in the OCC the relation between DEHP's biomarkers and FSIQ tended to be inverse but imprecise (p-value ≥ 0.10). No associations were found in the PCB cohort. FSIQ was not associated with HEXAMOLL® DINCH in any cohort. In conclusion, these results do not provide evidence of an association between concurrent phthalate/DINCHHEXAMOLLR DINCH exposure and IQ in children.
PB MDPI AG
YR 2022
FD 2022-09-13
LK http://hdl.handle.net/10668/21590
UL http://hdl.handle.net/10668/21590
LA en
NO Rosolen V, Giordani E, Mariuz M, Parpinel M, Ronfani L, Vecchi Brumatti L, et al. Concurrent Assessment of Phthalates/HEXAMOLL® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies. Toxics. 2022 Sep 16;10(9):538.
DS RISalud
RD Apr 5, 2025