RT Journal Article
T1 Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization
A1 Pozo-Torres, Esther
A1 Caro, Carlos
A1 Avasthi, Ashish
A1 Páez-Muñoz, Jose María
A1 García-Martín, María Luisa
A1 Fernández, Inmaculada
A1 Pernia Leal, Manuel
K1 Catecoles
K1 Ligandos
K1 Nanopartículas del metal
K1 Nanomedicina
K1 Compuestos férricos
K1 Química Clic
AB Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications because of the high functionalization efficiency of their surfaces with biomolecules, which facilitates their bio-compatibilization. However, the design and synthesis of clickable NPs is still challenging because of the complexity of the chemistry on the magnetic NP surface, thus robust methods that improve the ligand synthesis and the transfer of magnetic NPs in physiological media being in high-demand. In this work, we developed a versatile and enhanced synthetic route to fabricate potentially clickable IONPs of interest in nanomedicine. Catechol anchor ligands with different stereo-electronic features were synthetized from a hetero bi-functional PEG spacer backbone. The resulting catechol ligands transferred in good yields and high stability to magnetic NPs by an improved energetic ligand exchange method that combines sonication and high temperature. The azido functionalized IONPs exhibited excellent characteristics as T2 MRI contrast agents with low cytotoxicity, making these clickable magnetic NPs promising precursors for nanomedicines.
PB Royal Society of Chemistry
SN 1744-683X
YR 2020
FD 2020-03-05
LK http://hdl.handle.net/10668/3376
UL http://hdl.handle.net/10668/3376
LA en
NO Pozo-Torres E, Caro C, Avasthi A, Páez-Muñoz JM, García-Martín ML, Fernández I, et al. Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization. Soft Matter. 2020 Apr 1;16(13):3257-3266.
DS RISalud
RD Apr 6, 2025