TY - JOUR AU - Perez-Garcia, Jose Manuel AU - Vaz Batista, Marta AU - Cortez, Patricia AU - Ruiz-Borrego, Manuel AU - Cejalvo, Juan Miguel AU - de la Haba-Rodriguez, Juan AU - Garrigos, Laia AU - Racca, Fabricio AU - Servitja, Sonia AU - Blanch, Salvador AU - Gion, Maria AU - Nave, Monica AU - Fernandez-Abad, Maria AU - Martinez-Bueno, Alejandro AU - Llombart-Cussac, Antonio AU - Sampayo-Cordero, Miguel AU - Malfettone, Andrea AU - Cortes, Javier AU - Braga, Sofia PY - 2023 DO - 10.1093/neuonc/noac144 UR - http://hdl.handle.net/10668/19821 T2 - Neuro-oncology AB - Trastuzumab deruxtecan (T-DXd) has shown durable antitumor activity in pretreated patients with HER2-positive advanced breast cancer (ABC), but its efficacy has not yet been evaluated in patients with active brain metastases (BMs). DEBBRAH aims to... LA - en PB - Oxford University Press KW - HER2-positive KW - T-DXd KW - Advanced breast cancer KW - Brain metastases KW - Trastuzumab deruxtecan KW - Humans KW - Female KW - Breast neoplasms KW - Quality of life KW - Receptor, ErbB-2 KW - Antibodies, monoclonal, humanized KW - Trastuzumab KW - Camptothecin KW - Central nervous system TI - Trastuzumab deruxtecan in patients with central nervous system involvement from HER2-positive breast cancer: The DEBBRAH trial. TY - research article VL - 25 ER -