RT Journal Article
T1 Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study
A1 Moreno-López, Laura
A1 Stamatakis, Emmanuel A
A1 Fernández-Serrano, Maria José
A1 Gómez-Río, Manuel
A1 Rodríguez-Fernández, Antonio
A1 Pérez-García, Miguel
A1 Verdejo-García, Antonio
K1 Trastornos relacionados con el uso de sustancias
K1 Tomografía de Emisión de Positrones
K1 Abuso de Marihuana
K1 Dependencia de Heroína
K1 Trastornos Relacionados con Cocaína
K1 Alcoholismo
K1 N-Metil-3,4-metilenodioxianfetamina
K1 Conducta Adictiva
K1 Encéfalo
K1 Neuroimagen Funcional
K1 Humanos
K1 Vías Nerviosas
AB INTRODUCTIONFunctional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings from such studies may be relevant to implement specific interventions for treatment. The aim of this study was to examine the association between resting-state regional brain metabolism (measured with 18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and the severity of use of cocaine, heroin, alcohol, MDMA and cannabis in a sample of polysubstance users with prolonged abstinence from all drugs used.METHODSOur sample consisted of 49 polysubstance users enrolled in residential treatment. We conducted correlation analyses between estimates of use of cocaine, heroin, alcohol, MDMA and cannabis and brain metabolism (BM) (using Statistical Parametric Mapping voxel-based (VB) whole-brain analyses). In all correlation analyses conducted for each of the drugs we controlled for the co-abuse of the other drugs used.RESULTSThe analysis showed significant negative correlations between severity of heroin, alcohol, MDMA and cannabis use and BM in the dorsolateral prefrontal cortex (DLPFC) and temporal cortex. Alcohol use was further associated with lower metabolism in frontal premotor cortex and putamen, and stimulants use with parietal cortex.CONCLUSIONSDuration of use of different drugs negatively correlated with overlapping regions in the DLPFC, whereas severity of cocaine, heroin and alcohol use selectively impact parietal, temporal, and frontal-premotor/basal ganglia regions respectively. The knowledge of these associations could be useful in the clinical practice since different brain alterations have been associated with different patterns of execution that may affect the rehabilitation of these patients.
PB Public Library of Science
YR 2012
FD 2012-06-29
LK http://hdl.handle.net/10668/651
UL http://hdl.handle.net/10668/651
LA en
NO Moreno-López L, Stamatakis EA, Fernández-Serrano MJ, Gómez-Río  M, Rodríguez-Fernández A, Pérez-García M et al.  Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study. PLoS One. 2012;7(6):e39830.
DS RISalud
RD Apr 11, 2025