RT Journal Article
T1 Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions.
A1 Pallares, Christian
A1 Hernández-Gómez, Cristhian
A1 Appel, Tobías Manuel
A1 Escandón, Kevin
A1 Reyes, Sergio
A1 Salcedo, Soraya
A1 Matta, Lorena
A1 Martínez, Ernesto
A1 Cobo, Sara
A1 Mora, Laura
A1 Marín, Adriana
A1 Correa, Adriana
A1 De La Cadena, Elsa
A1 Rodríguez-Baño, Jesús
A1 Villegas, María Virginia
K1 Antibiotic resistance
K1 Antimicrobial resistance
K1 Antimicrobial stewardship
K1 Antimicrobial stewardship program
K1 Colombia
K1 Hospital epidemiology
AB Antimicrobial stewardship programs (ASPs) have become a fundamental pillar in optimizing antimicrobial usage, improving patient care, and reducing antimicrobial resistance (AMR). Herein we evaluated the impact of an ASP on antimicrobial consumption and AMR in Colombia. We designed a retrospective observational study and measured trends in antibiotic consumption and AMR before and after the implementation of an ASP using interrupted time series analysis over a 4-year period (24 months before and 24 months after ASP implementation). ASPs were implemented according to the available resources in each of the institutions. Before ASP implementation, there was a trend toward an increase in the antibiotic consumption of all measured antimicrobials selected. Afterward, an overall decrease in antibiotic consumption was observed. The use of ertapenem and meropenem decreased in hospital wards, while a decrease in the use of ceftriaxone, cefepime, piperacillin/tazobactam, meropenem, and vancomycin was observed in intensive care units. After ASP implementation, the trend toward an increase of oxacillin-resistant Staphylococcus aureus, ceftriaxone-resistant Escherichia coli, and meropenem-resistant Pseudomonas aeruginosa was reversed. In our study, we showed that ASPs are a key strategy in tackling the emerging threat of AMR and have a positive impact on antibiotic consumption and resistance.
YR 2022
FD 2022-05-02
LK http://hdl.handle.net/10668/20271
UL http://hdl.handle.net/10668/20271
LA en
DS RISalud
RD Apr 6, 2025