RT Journal Article
T1 Structured intermittent interruption of chronic HIV infection treatment with highly active antiretroviral therapy: Effects on leptin and TNF-alpha.
A1 Montes de Oca-Arjona, M
A1 Pérez-Cano, R
A1 Garcia-Juárez, R
A1 Martín-Aspas, A
A1 Fernández-Gutiérrez del Alamo, C
A1 Girón-González, J A
K1 RNA, Viral
K1 Receptors, Leptin
K1 Receptors, Tumor Necrosis Factor, Type I
K1 Receptors, Tumor Necrosis Factor, Type II
K1 Triglycerides
K1 Tumor Necrosis Factor-alpha
K1 Leptin receptor, human
K1 Cholesterol
K1 Leptin
K1 ARN Viral
K1 Receptores Tipo I de Factores de Necrosis Tumoral
K1 Receptores de Leptina
K1 Receptores Tipo II del Factor de Necrosis Tumoral
K1 Triglicéridos
K1 Factor de Necrosis Tumoral alfa
K1 Leptina
K1 Colesterol
K1 Receptores de leptina, humanos
K1 Recuento de Linfocito CD4
K1 Estudios de Casos y Controles
K1 Linfocitos T CD4-Positivos
K1 Enfermedad crónica
K1 Grosor de Pliegues Cutáneo
AB The changes in nutritional parameters and adipocytokines after structured intermittent interruption of highly active antiretroviral treatment of patients with chronic HIV infection are analyzed. Twenty-seven patients with chronic HIV infection (median CD4+ T cell count/microl: nadir, 394; at the beginning of structured interruptions, 1041; HIV viral load: nadir, 41,521 copies/ml; at the beginning of structured interruptions <50 copies/ml; median time of previous treatment: 60 months) were evaluated during three cycles of intermittent interruptions of therapy (8 weeks on/4 weeks off). CD4+ T cell count, HIV viral load, anthropometric measures, and serum concentrations of triglycerides, cholesterol, leptin, and tumor necrosis factor and its soluble receptors I and II were determined. After the three cycles of intermittent interruptions of therapy, no significant differences in CD4+ T cell count/microl, viral load, or serum concentrations of cholesterol or triglycerides with reference to baseline values were found. A near-significant higher fatty mass (skinfold thicknesses, at the end, 121 mm, at the beginning, 100 mm, p = 0.100), combined with a significant increase of concentration of leptin (1.5 vs. 4.7 ng/ml, p = 0,044), as well as a decrease in serum concentrations of soluble receptors of tumor necrosis factor (TNFRI, 104 vs. 73 pg/ml, p = 0.022; TNFRII 253 vs. 195 pg/ml, p = 0.098) were detected. Structured intermittent interruption of highly active antiretroviral treatment of patients with chronic HIV infection induces a valuable positive modification in markers of lipid turnover and adipose tissue mass.
PB Mary Ann Liebert Inc
SN 0889-2229
YR 2006
FD 2006-04
LK http://hdl.handle.net/10668/696
UL http://hdl.handle.net/10668/696
LA en
NO Montes de Oca-Arjona M, Pérez-Cano R, Garcia-Juárez R, Martín-Aspas A, Fernández-Gutiérrez del Alamo C, Girón-González JA. Structured intermittent interruption of chronic HIV infection treatment with highly active antiretroviral therapy: effects on leptin and TNF-alpha. AIDS Res. Hum. Retroviruses. 2006                         ; 22(4):307-14
NO This is a copy of an article published in the AIDS Research and Human Retroviruses © 2011 [copyright Mary Ann Liebert, Inc.]; AIDS Research and Human Retroviruses is available online at: http://online.liebertpub.com. Comparative Study; Journal Article;
DS RISalud
RD Apr 7, 2025