%0 Journal Article
%A Montes de Oca-Arjona, M
%A Pérez-Cano, R
%A Garcia-Juárez, R
%A Martín-Aspas, A
%A Fernández-Gutiérrez del Alamo, C
%A Girón-González, J A
%T Structured intermittent interruption of chronic HIV infection treatment with highly active antiretroviral therapy: Effects on leptin and TNF-alpha.
%D 2006
%@ 0889-2229
%U http://hdl.handle.net/10668/696
%X The changes in nutritional parameters and adipocytokines after structured intermittent interruption of highly active antiretroviral treatment of patients with chronic HIV infection are analyzed. Twenty-seven patients with chronic HIV infection (median CD4+ T cell count/microl: nadir, 394; at the beginning of structured interruptions, 1041; HIV viral load: nadir, 41,521 copies/ml; at the beginning of structured interruptions <50 copies/ml; median time of previous treatment: 60 months) were evaluated during three cycles of intermittent interruptions of therapy (8 weeks on/4 weeks off). CD4+ T cell count, HIV viral load, anthropometric measures, and serum concentrations of triglycerides, cholesterol, leptin, and tumor necrosis factor and its soluble receptors I and II were determined. After the three cycles of intermittent interruptions of therapy, no significant differences in CD4+ T cell count/microl, viral load, or serum concentrations of cholesterol or triglycerides with reference to baseline values were found. A near-significant higher fatty mass (skinfold thicknesses, at the end, 121 mm, at the beginning, 100 mm, p = 0.100), combined with a significant increase of concentration of leptin (1.5 vs. 4.7 ng/ml, p = 0,044), as well as a decrease in serum concentrations of soluble receptors of tumor necrosis factor (TNFRI, 104 vs. 73 pg/ml, p = 0.022; TNFRII 253 vs. 195 pg/ml, p = 0.098) were detected. Structured intermittent interruption of highly active antiretroviral treatment of patients with chronic HIV infection induces a valuable positive modification in markers of lipid turnover and adipose tissue mass.
%K RNA, Viral
%K Receptors, Leptin
%K Receptors, Tumor Necrosis Factor, Type I
%K Receptors, Tumor Necrosis Factor, Type II
%K Triglycerides
%K Tumor Necrosis Factor-alpha
%K Leptin receptor, human
%K Cholesterol
%K Leptin
%K ARN Viral
%K Receptores Tipo I de Factores de Necrosis Tumoral
%K Receptores de Leptina
%K Receptores Tipo II del Factor de Necrosis Tumoral
%K Triglicéridos
%K Factor de Necrosis Tumoral alfa
%K Leptina
%K Colesterol
%K Receptores de leptina, humanos
%K Recuento de Linfocito CD4
%K Estudios de Casos y Controles
%K Linfocitos T CD4-Positivos
%K Enfermedad crónica
%K Grosor de Pliegues Cutáneo
%~