RT Journal Article
T1 IgA Nephropathy Is the Most Common Underlying Disease in Patients With Anticoagulant-Related Nephropathy.
A1 Trujillo, Hernando
A1 Sandino, Justo
A1 Cavero, Teresa
A1 Caravaca-Fontan, Fernando
A1 Gutierrez, Eduardo
A1 Sevillano, Angel M
A1 Shabaka, Amir
A1 Fernandez-Juarez, Gema
A1 Rodriguez Doyagüez, Pablo
A1 Gimena Muñoz, Rocio
A1 Calle Garcia, Leonardo
A1 Cabello, Virginia
A1 Muñoz-Terol, Jose Manuel
A1 Garcia Santiago, Ana
A1 Toldos, Oscar
A1 Moreno, Juan Antonio
A1 Praga, Manuel
K1 IgA nephropathy
K1 Acute kidney injury
K1 Anticoagulation
K1 Hematuria
K1 Kidney biopsy
AB Anticoagulant-related nephropathy (ARN) is a relatively novel recognized entity characterized by hematuria-associated acute kidney injury (AKI) in the context of overanticoagulation. Preexisting or underlying kidney disease seems to be a predisposing factor; however, few studies have described histologic findings in patients with ARN. We aimed to evaluate underlying kidney pathology in patients on oral anticoagulation who presented an episode of AKI with hematuria in whom a kidney biopsy was performed. Retrospective observational multicenter case study in patients treated with oral anticoagulants who developed macroscopic or intense hematuria followed by AKI. Only patients with available kidney biopsy specimens were included. Histologic findings and clinical data throughout follow-up were analyzed. A total of 26 patients were included with a median age of 75 years (62-80) and a follow-up period of 10.1 months. Of the patients, 80% were male, and most cases (92%) were on anticoagulation with vitamin K antagonists (VKAs). At admission, median serum creatinine (SCr) level was 4.2 mg/dl (2.8-8.2), median international normalized ratio (INR) 2.4 (1.5-3.4), and 11 patients (42%) required acute dialysis during hospitalization. Kidney biopsy results revealed that all patients except 1 had an underlying nephropathy: IgA nephropathy (IgAN) in 19, probable IgAN in 1, diabetic nephropathy in 3, nephrosclerosis in 1, and idiopathic nodular glomerulosclerosis in 1. At 12 weeks after discharge, only 6 subjects (24%) attained complete kidney recovery whereas 7 (28%) remained on chronic dialysis. IgAN was the most common underlying kidney disease in our biopsy-proven series of ARN, in which a significant percentage of patients did not achieve kidney function recovery.
PB Elsevier
YR 2022
FD 2022-01-10
LK http://hdl.handle.net/10668/22197
UL http://hdl.handle.net/10668/22197
LA en
NO Trujillo H, Sandino J, Cavero T, Caravaca-Fontán F, Gutiérrez E, Sevillano ÁM, et al. IgA Nephropathy Is the Most Common Underlying Disease in Patients With Anticoagulant-Related Nephropathy. Kidney Int Rep. 2022 Jan 19;7(4):831-840
DS RISalud
RD Apr 23, 2025