RT Journal Article
T1 Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway.
A1 Moreno-Fernandez, Roman Dario
A1 Tabbai, Sara
A1 Castilla-Ortega, Estela
A1 Perez-Martin, Margarita
A1 Estivill-Torrus, Guillermo
A1 Rodriguez-de-Fonseca, Fernando
A1 Santin, Luis Javier
A1 Pedraza, Carmen
K1 LPA-LPA1 pathway receptor
K1 LPA1 receptor
K1 Ageing
K1 Limbic system
K1 Resilience
K1 Stress
AB Chronic stress affects health and the quality of life, with its effects being particularly relevant in ageing due to the psychobiological characteristics of this population. However, while some people develop psychiatric disorders, especially depression, others seem very capable of dealing with adversity. There is no doubt that along with the identification of neurobiological mechanisms involved in developing depression, discovering which factors are involved in positive adaptation under circumstances of extreme difficulty will be crucial for promoting resilience. Here, we review recent work in our laboratory, using an animal model lacking the LPA1 receptor, together with pharmacological studies and clinical evidence for the possible participation of the LPA1 receptor in mood and resilience to stress. Substantial evidence has shown that the LPA1 receptor is involved in emotional regulation and in coping responses to chronic stress, which, if dysfunctional, may induce vulnerability to stress and predisposition to the development of depression. Given that there is commonality of mechanisms between those involved in negative consequences of stress and in ageing, this is not surprising, considering that the LPA1 receptor may be involved in coping with adversity during ageing. Alterations in this receptor may be a susceptibility factor for the presence of depression and cognitive deficits in the elderly population. However, because this is only a promising hypothesis based on previous data, future studies should focus on the involvement of the LPA-LPA1 pathway in coping with stress and resilience in ageing.
PB Bentham Science Publishers Ltd.
YR 2017
FD 2017-06-30
LK http://hdl.handle.net/10668/11395
UL http://hdl.handle.net/10668/11395
LA en
NO Moreno-Fernandez RD, Tabbai S, Castilla-Ortega E, Perez-Martin M, Estivill-Torrus G, Rodriguez de Fonseca F, et al. Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway. Curr Neuropharmacol. 2018 Mar 5;16(3):271-283
NO This research was funded by the Andalusian Ministry of Economy, Innovation, Science and Employment (SEJ1863 to CP and CTS-643 to GE-T) and of Health (Nicolas Monardes programme, to GE-T); the Spanish Ministry of Economy and Competitiveness (PSI2013-44901-P to LJS and CP). Author EC-O. holds a grant from the Spanish Ministry of Economy and Competitiveness co-funded by European Research Development Fund (UE-ERDF) (code: PSI2015-73156-JIN). Author RDM-F holds a Grant of the Spanish Ministry of Education, Culture and Sports (FPU14/01610). Author ST holds a Grant of the Andalusian Ministry of Economy, Innovation, Science and Employment (FPDI 2016).
DS RISalud
RD Oct 13, 2025