RT Journal Article
T1 Sporulation is dispensable for the vegetable-associated life cycle of the human pathogen Bacillus cereus
A1 Antequera-Gómez, María Luisa
A1 Díaz-Martínez, Luis
A1 Guadix, Juan Antonio
A1 Sánchez-Tévar, Ana María
A1 Sopeña-Torres, Sara
A1 Hierrezuelo, Jesús
A1 Doan, Hung K.
A1 Leveau, Johan H. J.
A1 deVicente, Antonio
A1 Romero, Diego
K1 Bacillus cereus
K1 Emetics
K1 Enterotoxins
K1 Spores
K1 Food poisoning
K1 Eméticos
K1 Enterotoxinas
K1 Esporas
K1 Enfermedades transmitidas por los alimentos
AB Bacillus cereus is a common food-borne pathogen that is responsible for important outbreaks of food poisoning in humans. Diseases caused by B. cereus usually exhibit two major symptoms, emetic or diarrheic, depending on the toxins produced. It is assumed that after the ingestion of contaminated vegetables or processed food, spores of enterotoxigenic B. cereus reach the intestine, where they germinate and produce the enterotoxins that are responsible for food poisoning. In our study, we observed that sporulation is required for the survival of B. cereus in leaves but is dispensable in ready-to-eat vegetables, such as endives. We demonstrate that vegetative cells of B. cereus that are originally impaired in sporulation but not biofilm formation are able to reach the intestine and cause severe disorders in a murine model. Furthermore, our findings emphasise that the number of food poisoning cases associated with B. cereus is underestimated and suggest the need to revise the detection protocols, which are based primarily on spores and toxins.
PB John Wiley & Sons Ltd and Society for Applied Microbiology
YR 2021
FD 2021-05-06
LK http://hdl.handle.net/10668/3933
UL http://hdl.handle.net/10668/3933
LA en
NO Antequera-Gómez ML, Díaz-Martínez L, Guadix JA, Sánchez-Tévar AM, Sopeña-Torres S, Hierrezuelo J, et al. Sporulation is dispensable for the vegetable-associated life cycle of the human pathogen Bacillus cereus. Microb Biotechnol. 2021 Jul;14(4):1550-1565
DS RISalud
RD Apr 12, 2025